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This is the first book covering all aspects of high pressure biochemistry and biophysics of proteins.

Hydrostatic pressure is a powerful tool for study of biological systems. As a thermodynamic parameter, hydrostatic pressure has been known for a century to act on biological materials in a similar, but not identical, way to temperature. However, pressure was disregarded for a long time by biochemists mainly because the basic concepts (and the thermodynamics) focused on the chemical reactions involved and because general ideas on what pressure can add to the understanding of the behaviour of proteins were lacking. In recent decades, technological progress in the field of physics has shown, along with parameters such as temperature and solvent conditions, that pressure can be used for more refined thermodynamic and kinetic descriptions of biological processes and regulation of biological systems. The effects of pressure on proteins, nucleoproteins and membranes have recently been reviewed and several proceedings books have been published.

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Chromatographic Determination of Molecular Interactions describes the theory and practice of the measurement of molecular interactions by thin-layer, high performance liquid, and gas chromatography. Methods and various procedures used for the calculation of complex stability constants are compiled, and the stability constants of a wide variety of interactions determined by the various chromatographic techniques are included. New results of molecular interactions are covered, including those for protein-peptide and amino acid-nucleic acid bases. The book will appeal to biochemists, analytical chemists, molecular biologists, biotechnologists, biophysicists, and medicinal chemists. ... Read more

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The detection and neutralization of unexploded ordnance (UXO) has been of major concern for very many decades; at least since the First World War. UXO continues to be the subject of intensive research in many fields of science. While today's headlines emphasize the mayhem resulting from the placement of improvised explosive devices (IEDs), humanitarian landmine clearing continues to draw significant global attention as well. In many countries of the world, landmines threaten the population and hinder reconstruction and fast, efficient utilization of large areas of the mined land in the aftermath of military conflicts. The reports in this volume, written by world leaders from academia, Government and industry, describe how basic ideas from mathematics, radar, sonar and chemistry can be combined with ongoing improvements in hardware and computation, as well as very new advances in multisensor data fusion, to yield the promise of more sophisticated and accurate UXO detection and identification capabilities than currently exist.

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This revised and enlarged second edition is devoted to asymptotical questions of the theory of entire and plurisubharmonic functions. A separate chapter deals with applications in biophysics. The book is of interest to research specialists in theoretical and applied mathematics, postgraduates and students who are interested in complex and real analysis and its applications.

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The last decade presented the auditory world with the surprise that hair cells not only can detect and process mechanical energy, but are also able to produce it. Thanks to the active hair cell, ears can produce otoacoustic emissions. This book provides newest insights derived from current research into the biophysics and physiology of individual hair cells and integral hair cell systems such as the inner ear and the lateral line organ. ... Read more

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This book presents a comprehensive overview of the molecular and biological consequences of the posttranslational modification of proteins with ADP-ribose monomers and polymers. Part one focusses on chromatin-associated poly ADP-ribosylation reactions which have evolved in higher eukaryotes as modulators of chromatin functions. The significance of poly ADP-ribosylation in DNA repair, carcinogenesis, and gene expression during terminal differentiation is discussed in detail. Part two reviews mono ADP-ribosylation reactions which are catalyzed by prokaryotic and eukaryotic enzymes. Prominent consideration is given to the action of bacterial toxins, such as cholera toxin, pertussis toxin, and diphtheria toxin. These toxins have emerged as novel tools for the molecular probing of proteins involved in signal transduction and protein biosyntheses. ... Read more