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A great deal of progress has been made in defining GABA (gamma-aminobutyric acid) transmission in the brain.Volume 54 of the Advances in Pharmacology series has also provided new insights into fundamental features of neurotransmission in general, such as the importance of allosterism and coincident signaling in regulating receptor function and overall cellular activity.These studies have led to the design and development of new drugs and potential therapeutic agents.

Given the successes achieved over the first 50 years of GABA research, it is certain the 6th decade will yield its share of surprising discoveries and new insights.Published in this volume are articles providing thoughts and perspectives on this topic, some with the benefit of hindsight, others in the context of recent findings, but all with a hint, or prediction, of what the future holds as the secrets of GABA neurotransmission continue to unfold.

Advances in Pharmacology is available online on ScienceDirect - full-text online of volumes 48 onwards.

*GABA is an amino acid found in mammalian brain
*Articles written by leading investigators in the field
*Provides new insights into fundamental features of neurotransmission ... Read more

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This volume covers the latest advances in the mechanisms of pathogenesis of the HIV-1 virus on target cells.Its companion volume, Advances in Pharmacology 56, shows how new developments in understanding the virus translate to the clinical setting. ... Read more

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Each volume of Advances in Pharmacology provides a rich collection of reviews on timely topics. Emphasis is placed on the molecular bases of drug action, both applied and experimental. ... Read more

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The cumulative death toll from AIDS has reached 16.3 million individuals, and more than 33 million persons are currently living with HIV-1. Although it is one of the most-widely studied viruses, many mysteries remain about this pathogen. In this comprehensive two-volume set, HIV-1: Molecular Biology and Pathogenesis, leading investigators in HIV research present a timely picture of the molecular mechanisms which guide HIV-1 expression and replication and provide the most current clinical strategies for combating this virus. Twenty-six teams of experts unravel structure-function interactions of HIV-1 with host cells and the resulting pathological consequences, review strategies fo treatment, and describe ongoing progress in developing animal models and prophylactic vaccines.
The two volumes, covering viral mechanisms and clinical applications, respectively, are written by an international collection of AIDS expers from North America, Europe, Australia, and Asia.

Key Features
* Detailed insights into viral packaging, expression, and assembly
* Mechanistic understanding of how HIV interacts with receptors and infects cells
* Delineation of virally encoded regulatory processes unique to HIV
* Clinical Applications:
* An updated review of current chemotherapeutics for HIV
* New concepts in the discovery and design of novel anti-HIV drugs
* The latest developments in HIV-vaccine research ... Read more

Product Description
Each volume of Advances in Pharmacology provides a rich collection of reviews on timely topics. Emphasis is placed on the molecular bases of drug action, both applied and experimental. ... Read more

Product Description
The cumulative death toll from AIDS has reached 16.3 million individuals, and more than 33 million persons are currently living with HIV-1. Although it is one of the most-widely studied viruses, many mysteries remain about this pathogen. In this comprehensive two-volume set, HIV-1: Molecular Biology and Pathogenesis, leading investigators in HIV research present a timely picture of the molecular mechanisms which guide HIV-1 expression and replication and provide the most current clinical strategies for combating this virus. Twenty-six teams of experts unravel structure-function interactions of HIV-1 with host cells and the resulting pathological consequences, review strategies fo treatment, and describe ongoing progress in developing animal models and prophylactic vaccines.
The two volumes, covering viral mechanisms and clinical applications, respectively, are written by an international collection of AIDS expers from North America, Europe, Australia, and Asia.

Key Features
* Detailed insights into viral packaging, expression, and assembly
* Mechanistic understanding of how HIV interacts with receptors and infects cells
* Delineation of virally encoded regulatory processes unique to HIV
* Clinical Applications:
* An updated review of current chemotherapeutics for HIV
* New concepts in the discovery and design of novel anti-HIV drugs
* The latest developments in HIV-vaccine research ... Read more

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Hormones and Signaling focuses on the mechanisms of gene regulation at the cellular level. It also describes the actions of hormones in modulating gene regulation and animal development.

Key Features
* Glococorticoid and mineralcorticoid signaling
* Orphan nuclear receptors
* Nuclear receptor coactivators
* Cytokines and STAT signaling
* Coordination of cAMP signaling events through PKA anchoring
* G protein-coupled extracellular Ca2+ (Ca2+0)-sensing receptor (CaR)
* Pancreatic islet development
* Genetic analysis of androgen receptors in development and disease
* Antioprogestin regulable gene switch for induction of gene expression in vivo
* Steroid receptor knockout model ... Read more

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This volume in Advances in Pharmacology focuses on all aspects of catecholamine research, from very basic to medical. It is broad based and covers many areas within physiology and medicine. ... Read more

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Volume 32 contains issues of interest to scientists working in pharmacology, biochemistry, and physiology, particularly to those in HIV, cancer, neurology, and cardio-vascular research and medicine. The chapters on new approaches to cancer therapy and schizophrenia will be of special interest to pharmacologists. Each volume of Advances in Pharmacology provides a rich collection of reviews on timely topics. Emphasis is placed on the molecular bases of drug action, both applied and experimental. ... Read more

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Each volume of Advances in Pharmacology provides a rich collection of reviews on timely topics. Emphasis is placed on the molecular basis of drug action, both applied and experimental. ... Read more

Product Description
Each volume of Advances in Pharmacology provides a rich collection of reviews on timely topics. Emphasis is placed on the molecular basis of drug action, both applied and experimental.
Conjugation reactions have long been associated with the detoxification of xenobiotics. Recent studies suggest that Phase II reactions are an important mechanism for the bioactivation of xenobiotics.
This special volume of Advances in Pharmacology features a two-color dust jacket.

Key Features
* Summarizes the most recent information on:
* Xenobiotic conjugation
* Drug toxicity, hypersensitivity, and targeting
Chemical carcinogenesis
* Glutathione-, sulfate conjugate-, and glucuranide conjugate-dependent toxicity
* Bioactivation and bioconversion ... Read more

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Each volume of Advances in Pharmacology provides a rich collection of reviews on timely topics. Emphasis is placed on the molecular bases of drug action, both applied and experimental.

Key Features
* This volume includes reviews on some of the hottest topics in pharmacology, including:
* Multidrug resistance and the MDR1 gene in gene therapy
* Regulation of calcium channels in epithelial cells
* Gene therapy and vascular disease
* Potential therapeutic applications for Heparin
* Calcium channel blockers
* Antithrombotic agents
* Regulation of potassium channels in epithelial cells ... Read more

Product Description
Each volume of Advances in Pharmacology provides a rich collection of reviews on timely topics. Emphasis is placed on the molecular basis of drug action, both applied and experimental. ... Read more

Product Description
Each volume of Advances in Pharmacology provides a rich collection of reviews on timely topics. Emphasis is placed on the molecular bases of drug action, both applied and experimental. ... Read more

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Drug–Drug Interactions is a comprehensive review of the scientific and regulatory perspectives of drug–drug interactions from the point-of-view of academia, industry, and government regulatory agencies. This book is intended for professionals in the pharmaceutical industry, health care, and governmental regulatory agencies. Topics of interest include the mechanistic understanding of drug–drug interactions, the prediction of drug–drug interaction potential of new drugs, and the avoidance of clinically significant drug–drug interaction in patients.

Key Features
* Provides useful references on the science of drug-drug interactions
* Describes in a basic and comprehensive manner drug-drug interactions from the mechanistic viewpoint
* Contains original data from academic and industrial laboratories
* Presents an overview of regulatory agency positions ... Read more

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Advances in Pharmacology provides a rich collection of reviews on timely topics. Emphasis is placed on the molecular bases of drug action, both applied and experimental. For easy reference, this volume provides a cumulative subject index covering Volumes 25-44. ... Read more

Product Description
Each volume of Advances in Pharmacology provides a rich collection of reviews on timely topics. Emphasis is placed on the molecular bases of drug action, both applied and experimental. ... Read more

Product Description
Each volume of Advances in Pharmacology provides a rich collection of reviews on timely topics. Emphasis is placed on the molecular bases of drug action, both applied and experimental. ... Read more

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This volume is dedicated to the topic of cyclic GMP. Chapters include discussions on the guanylyl cyclase and phosphodiesterase isoenzyme families for cyclic GMP synthesis and hydrolysis, cyclic GMP-dependent protein kinases, and various hormones and ligands that regulate cyclic GMP formation and/or metabolism. Several chapters also deal with some of the effects of cyclic GMP on other second messengers such as calcium ion transport and smooth muscle relaxation. Some clinical studies with cyclic GMP and atrial natriuretic peptide are also discussed. The last chapter raises many important questions in the field that remain to be addressed.

Key Features
* Isoforms of guanylyl cyclase and phosphodiesterase isoenzyme families for cyclic GMP synthesis and hydrolysis
* Cyclic GMP-dependent protein kinase
* Hormones and ligands that regulate GMP formation and/or metabolism
* Effects of cyclic GMP on other second messengers and some functions such as smooth muscle relaxation and ion transport
* Clinical studies with cyclic GMP and atrial natriuretic peptide
* Important questions and experiments for the future ... Read more

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Each volume of Advances in Pharmacology provides a rich collection of reviews on timely topics. Emphasis is placed on the molecular bases of drug action, both applied and experimental. Volume 40, GeneTherapy, features important new research on gene transfers and therapy in the herpes simplex virus, anti-tumor immunity, steroid receptors, cystic fibroses, and more.

Key Features
* It provides an excellent overview on a series of topics on gene therapy for the serious investigator ... Read more