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Schizencephaly: more detail

The Official Parent's Sourcebook on Schizencephaly: A Revised and Updated Directory for the Internet Age by ICON Health Publications, 2004-02-13

Schizencephaly: An entry from Thomson Gale's <i>Gale Encyclopedia of Neurological Disorders</i> by Peter, MD Lin, 2005

The Official Parent's Sourcebook On Schizencephaly by Icon Health Publications, 2004

lists with details

ACR Learning File Web
The findings of a gray matter lined cleft extending through the entire hemisphereinto the lateral ventricle is diagnostic of schizencephaly. Return to top.
http://www.learningfile.com/learning_file/viewcase.php?section=nu&case_num=705
Cephalic Disorders - Types - Neurologychannel
Colpocepaly, Holoprosencephaly, Hydranencephaly, Iniencephaly, Lissencephaly, Megalencephaly,Microcephaly, Porencephaly, schizencephaly, Other Rare Cephalic
http://www.neurologychannel.com/cephalicdisorders/hydranencephaly.shtml

Extractions: Hydranencephaly is a rare and extreme form of porencephaly. The hemispheres of the cerebrum are absent and replaced by sacs filled with cerebrospinal fluid (CSF). In most cases, the cerebellum and brainstem are formed normally. Causes Vascular injuries, infections, or trauma after the 12th week of pregnancy result in malformations of the brain. Symptoms Some infants with hydranencephaly may have seizures, myoclonus (sudden, rapid, involuntary twitches or jerks), and respiratory problems at birth. Most appear normal and have normal spontaneous reflexes, such as sucking, swallowing, crying, and moving the arms and legs. Within a few weeks these infants become irritable and develop hypertonia, an abnormal increase in muscle tone. Seizures and hydrocephalus usually follow within a few months, and there may be symptoms of visual impairment, lack of growth, deafness, blindness, paralysis, and intellectual deficits.
Cleveland Clinic Health System - Health Information
Search Results The following information is available for the topic schizencephaly.Please select one. Care Treatment. , schizencephaly. New Search.
http://www.cchs.net/health/getcontents.asp?DocID=do-query&TopicId=1353
IComm: File Not Found!
Scheie Syndrome .. National MPS Society http//members.aol.com/mpssociety.schizencephaly ..
http://www.icomm.ca/geneinfo/s.htm
Abstract
Diagnostic Neuroradiology. Morphological features and associated anomalies ofschizencephaly in the clinical population detailed analysis of MR images.
http://link.springer-ny.com/link/service/journals/00234/contents/01/00719/s00234

Extractions: N. Hayashi , Y. Tsutsumi and A. J. Barkovich Department of Radiology, Faculty of Medicine, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan Department of Radiology, National Okura Hospital, Tokyo, Japan Department of Radiology, Section of Neuroradiology, University of California San Francisco, San Francisco, USA Abstract. Keywords. Schizencephaly - Porencephaly - Polymicrogyria - MRI E-mail: naoto-tky@umin.ac.jp
Abstract
© SpringerVerlag 2002. Diagnostic Neuroradiology. Polymicrogyriawithout porencephaly/schizencephaly. MRI analysis of the spectrum
http://link.springer-ny.com/link/service/journals/00234/contents/02/00793/s00234

Extractions: N. Hayashi , Y. Tsutsumi and A. J. Barkovich Department of Radiology, Faculty of Medicine, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, Japan Section of Neuroradiology, University of California San Francisco, San Francisco, California, USA Department of Radiology, National Okura Hospital, Tokyo, Japan Abstract. Keywords. Polymicrogyria - MRI - Developmental anomaly E-mail: naoto-tky@umin.ac.jp
Dorlands Medical Dictionary
schizencephaly (schiz·en·ceph·a·ly) (skiz²schwansef¢schwa-le)schiz- + Gr. enkephalos brain schizencephalic porencephaly.
http://www.mercksource.com/pp/us/cns/cns_hl_dorlands.jspzQzpgzEzzSzppdocszSzuszS
CancerGene EMX2
Faiella A;Brunelli S;Granata T;D'Incerti L;Cardini R;Lenti C;Battaglia G;BoncinelliE A number of schizencephaly patients including 2 brothers are heterozygous
http://caroll.vjf.cnrs.fr/cancergene/CG1887.html

Extractions: GDB SwissProt LocusLink Keywords Mutation Diseases Endometrial Neoplasms Note To examine the potential function of EMX2 in endometrial tumorigenesis, Noonan et al. (2001, UI:21433821 ) investigated 20 primary tumors and 6 endometrial cancer cell lines for mutations. Two primary tumors had mutations. Inactivation or reduced expres sion of EMX2 in cancers, coupled with increased expression in the quiescent endometrium, indicate that this homeodomain gene is involved in maintenance of the differentiated state.
Mioti: Medical Condition
Condition schizencephaly. NINDS schizencephaly Information Page. Informationfrom the National Institute of Neurological Disorders and Stroke. General Topics.
http://www.mioti.com/cat/condition/condition.asp?Cat=Schizencephaly
Schizencephaly
schizencephaly NINDS schizencephaly http//www.ninds.nih.gov Information sheetcompiled the National Institute of Neurological Disorders and Stroke.
http://www.medlina.com/schizencephaly.htm
CLASSIFIEDS.TERADEX.COM - Health/Fitness/Diseases/Genetic Disorders/Schizencepha
CLASSIFIEDS.TERADEX.COM Health/Fitness/Diseases/Genetic Disorders/schizencephaly. CLASSIFIEDS/ Health/Fitness / Diseases / Genetic Disorders / schizencephaly.
http://classifieds.teradex.com/Health_Fitness/Diseases/Genetic_Disorders/Schizen
Katalog : : Health : Conditions_and_Diseases : Genetic_Disorders : Schi
Translate this page NINDS schizencephaly - Information sheet compiled the National Instituteof Neurological Disorders and Stroke. Pediatric Database
http://www.netz-tipp.de/kat/Health/Conditions_and_Diseases/Genetic_Disorders/Sch

Extractions: Anzeige: Verdienen Sie Geld mit Ihren ungenutzten Domains! Welt English Health ... Genetic Disorders : Schizencephaly Seite (URL) vorschlagen Eintrag in weiteren Suchmaschinen Help build the largest human-edited directory on the web. Submit a Site Open Directory Project Become an Editor In einigen Teilen modifizierte Version des DMOZ.
The 18-23-week Scan - Chapter 2.09
The 1823-week scan. Gianluigi Pilu Kypros H. Nicolaides. DESTRUCTIVE CEREBRALLESIONS. These lesions include hydranencephaly, porencephaly and schizencephaly.
http://www.fetalmedicine.com/18-23scanbook/Chapter2/chap02-09.htm

Extractions: These lesions include hydranencephaly, porencephaly and schizencephaly. In hydranencephaly , there is absence of the cerebral hemispheres with preservation of the mid-brain and cerebellum. In porencephaly , there are cystic cavities within the brain that usually communicate with the ventricular system, the subarachnoid space or both. Schizencephaly is associated with clefts in the fetal brain connecting the lateral ventricles with the subarachnoid space. Destructive cerebral lesions are found in about 1 per 10,000 births. Hydranencephaly is a sporadic abnormality that may result from widespread vascular occlusion in the distribution of the internal carotid arteries, prolonged severe hydrocephalus, or an overwhelming infection such as toxoplasmosis or cytomegalovirus. Porencephaly may be caused by infarction of the cerebral arteries or hemorrhage into the brain parenchyma. Schizencephaly may be a primary disorder of brain development or it may be due to bilateral occlusion of the middle cerebral arteries. Complete absence of echoes from the anterior and middle fossae distinguishes hydranencephaly from severe hydrocephalus in which a thin rim of remaining cortex and the mid-line echo can always be identified. In porencephaly, there are one or more cystic areas in the cerebral cortex, which usually communicates with the ventricle; the differential diagnosis is from intracranial cysts (arachnoid, glyo-ependymal), that are usually found either within the scissurae or in the mid-line and compress the brain. In schizencephaly, there are bilateral clefts extending from the lateral ventricles to the subarachnoid space. Schizencephaly is usually associated with absence of the cavum septum pellucidum.
Lissencephaly
Microlissencephaly (MLIS), NormanRoberts Syndrome (NRS), Lissencephaly with CerebellarHypoplasia (LCH), Polymicrogyria (PMG), schizencephaly (SCH), Muscle-Eye
http://www.my-journey.net/pages/lissencephaly.html

Extractions: Lissencephaly Isolated Lissencephaly Sequence (ILS), X-Linked Lissencepahly (XLIS), Subcortical Band Heterotopia (SBH), Miller-Dieker Syndrome (MDS), Microcephaly, Microlissencephaly (MLIS), Norman-Roberts Syndrome (NRS), Lissencephaly with Cerebellar Hypoplasia (LCH), Polymicrogyria (PMG), Schizencephaly (SCH), Muscle-Eye-Brain (MEB) Disease, and Walker-Warburg Syndrome (WWS), Chromosome 17p13.3 deletion Lissencephaly Network c/o Debbie Bloor
Health Library - Schizencephaly
SelfHelp Resources Information about national and local self-help organizationsand support groups. schizencephaly. Self Help Clearinghouse. Schiz Kidz Buddies.
http://www.baylorhealth.com/library/healthguide/selfhelp/topic.asp?hwid=shc29sch
Health Library - Schizencephaly
Logo. Customized health information for you and your family Site Search AdvancedSearch. schizencephaly. Self Help Clearinghouse. Schiz Kidz Buddies.
http://www.stjosephhealth.org/library/healthguide/SelfHelp/topic.asp?hwid=shc29s
Health Conditions And Diseases Genetic Disorders Schizencephaly Polish Yellow Pa
Health Conditions and Diseases Genetic Disorders schizencephaly552312 Polish Yellow Pages YP.pl.
http://www.yellowpages.pl/ca/552312/Health/Conditions_and_Diseases/Genetic_Disor
NEURORADIOLOGY
axial space with temporal lobe atrophy. Diagnosis schizencephaly (opentype). Discussion Clinical Findings Patients may present with
http://www.indianradiologist.com/neuroradiology9.htm

Extractions: Failure of the normal migration of neurons from the germinal matrix zone at 1-5 months of gestation. A gray matter lined parenchymal cleft develops which extends from the subarachnoid space to the subependyma of the lateral ventricles. Schizencephaly occurs when there is a failure of the normal migration of neurons from the germinal matrix zone at 1-5 months of gestation. Some theories suggest that possible causes of this are in-utero stroke, early gestational viral infections, and recent Italian research has linked Schizencephaly with a mutated gene called the Homeobox gene EMX-2. If the gene EMX-2 is missing or defective, nerve cell growth and migration will not occur normally and this
BRI - Publications - ABSTRACTS
Twins with different temporal lobe malformations schizencephaly and arachnoidcyst. schizencephaly is generally regarded as unrelated to arachnoid cysts.
http://www.brain.org.au/publications/GDJ_abs.html
Discus26
CASE 40 DISCUSSION schizencephaly is an uncommon structural disorder of cerebralcortical development, characterized by congenital clefts spanning the cerebral
http://www.medicine.cmu.ac.th/dept/radiology/pedrad/discus40.html

Extractions: Schizencephaly is an uncommon structural disorder of cerebral cortical development, characterized by congenital clefts spanning the cerebral hemispheres from the pial surface to the lateral ventricles and lined by cortical gray matter [1]. This lesion, which occurs between the third and fourth month of gestation, may be due to an antenatal environmental incident or may be of a genetic origin. The clinical features of schizencephaly are extremely variable. The severity of symptoms is related to the amount of the brain involved. Children with unilateral schizencephaly present with hemiparesis and mild mental delay, while children with bilateral cleft are tetraparetic with severe mental deficits [1]. The clefts are divided into those with closed lips and those with open lips. In the clefts with closed lips, the walls oppose one another directly, obliterating the CSF space within the cleft at that point. When the lips are open, CSF fills the cleft all the way from the lateral ventricle to the subarachnoid spaces surrounding the hemispheres. The clefts, which can be unilateral or bilateral, are most commonly located near the pre- and post-central gyri. The septum pellucidum is absent in about 80% of patients with schizencephaly [2]. These abnormalities can be seen with any imaging modality, but appear best demonstrated with magnetic resonance imaging. Imaging studies of schizencephaly show a cleft through the affected hemisphere. Gray matter, typically characterized by a bumpy outer surface and an irregular gray matter-white matter junction, lines the cleft. The gyral pattern of the cortex adjacent to the cleft is usually abnormal, with sulci that radiate into the cleft. The gray matter lining the cleft may extend into the ventricle in the form of subependymal heterotopia [2]. On proton density and T2-weighted images, the lining of the cleft is isointense to gray matter. On MRI differentiation of schizencephaly from a porencephalic cyst is based on demonstration of gray matter along the entire length of the cleft in schizencephaly, whereas with porencephaly the cleft extends through both gray and white matter so that there will also be white matter abutting the CSF cyst [3].

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