1. Thomas R. Cech - Autobiography thomas R. cech – Autobiography. of my research group's discoveries, more thana dozen national and international awards preceded the nobel Prize for http://www.nobel.se/chemistry/laureates/1989/cech-autobio.html

Grandfather Josef, a shoemaker, immigrated to the U.S. from Bohemia in 1913. My other grandparents, also of Czech origin, were first-generation Americans. My father was and is a physician, my mother the homemaker. I was born in Chicago on December 8, 1947. The safe streets and good schools of Iowa City, Iowa provided the backdrop for the childhood years of my sister Barbara,my brother Richard and myself. My father, who loved physics as much as medicine, interjected a scientific approach and point of view into most every family discussion. I discovered science for myself in fourth grade, collecting rocks and minerals and worrying about how they were formed. By the time I was in junior high school, I would knock on Geology professors' doors at the University of Iowa , asking to see models of crystal structures and to discuss meteorites and fossils. In 1966 I entered Grinnell College , where I was to derive as much enjoyment studying Homer's Odyssey, Dante's Inferno, and Constitutional History as Chemistry. I met Carol over the melting point apparatus in a make-up Organic Chemistry lab, starting the partnership of our lives that is now more than 20 years old.

2. Thomas R. Cech - Nobel Lecture thomas R. cech – nobel Lecture. Selfsplicing Other Resources. thomasR. cech Autobiography nobel Lecture Other Resources. 1988, 1990. http://www.nobel.se/chemistry/laureates/1989/cech-lecture.html

Self-splicing and enzymatic activity of an intervening sequence RNA from Tetrahymena Nobel Lecture, December 8, 1989 From Nobel Lectures , Chemistry 1981-1990. The Lecture in pdf-format Download Adobe Acrobat Reader is free software that lets you view and print Adobe Portable Document Format (PDF) files. The Nobel Prize in Chemistry 1989 Press Release Presentation Speech Illustrated Presentation ... Other Resources The 1989 Prize in: Physics Chemistry Physiology or Medicine Literature ... Economic Sciences Find a Laureate: Last modified June 27, 2002 The Official Web Site of The Nobel Foundation

3. Thomas R. Cech Winner Of The 1989 Nobel Prize In Chemistry thomas R. cech, a nobel Prize Laureate in Chemistry, at the nobelPrize Internet Archive. thomas R. cech. 1989 nobel Laureate in http://almaz.com/nobel/chemistry/1989b.html

T HOMAS R C ECH 1989 Nobel Laureate in Chemistry for their discovery of catalytic properties of RNA. Background Born: 1947 Residence: U.S.A. Affiliation: University of Colorado, Boulder, CO Featured Internet Links Prize Co-recipient: Sidney Altman The Cech Laboratory page current research Search WWW Search The Nobel Prize Internet Archive Nobel News Links Thomas R. Cech receives Nobel Prize for Chemistry Links added by Nobel Internet Archive visitors Winner of The Gairdner Foundation Int'l Award (submitted by glengair@inforamp.net Modern or "strong" version of panspermia (submitted by Brig Klyce Thomas R. Cech's HHMI Research in Progress The Cech Lab Home Page Thomas R. Cech – Autobiography (submitted by Chinnappan Baskar Back to The Nobel Prize Internet Archive Literature Peace ... Medicine We always welcome your feedback and comments

4. Index Of Nobel Laureates In Chemistry ALPHABETICAL LISTING OF nobel PRIZE LAUREATES IN CHEMISTRY. Name, Year Awarded. Alder,Kurt, 1950. Calvin, Melvin, 1961. cech, thomas R. 1989. Corey, Elias James, 1990. http://almaz.com/nobel/chemistry/alpha.html

ALPHABETICAL LISTING OF NOBEL PRIZE LAUREATES IN CHEMISTRY Name Year Awarded Alder, Kurt Altman, Sidney Anfinsen, Christian B. Arrhenius, Svante August ... Medicine We always welcome your feedback and comments

5. HHMI News: Thomas R. Cech To Become The Next President Of The Howard Hughes Medi Institute have selected thomas R. cech of the University of Colorado at Boulder tobecome the next president of the Institute. cech, who won the nobel Prize in http://www.hhmi.org/news/cech.html

INSTITUTE NEWS RESEARCH NEWS GRANT ANNOUNCEMENTS SCIENCE EDUCATION NEWS INSTITUTE NEWS ... HHMI HOME ALSO OF INTEREST Dr. Cech's Research Background Autobiographical Sketch High-Resolution Photos Thomas R. Cech to Become the Next President of the Howard Hughes Medical Institute Thomas R. Cech The Trustees of the Howard Hughes Medical Institute have selected Thomas R. Cech of the University of Colorado at Boulder to become the next president of the Institute. Cech, who won the Nobel Prize in chemistry in 1989, will assume the presidency next January. He will succeed Purnell W. Choppin, president of the Institute since 1987, who announced late last year that he would retire at the end of 1999. "The Trustees are delighted that Tom Cech has agreed to bring his creative leadership to the guidance of the Hughes Institute," said Hanna H. Gray, chairman of the HHMI Trustees and head of the committee that conducted the presidential search. "Professor Cech is a distinguished scientist of great accomplishment, with a profound understanding of the research world. As a Hughes investigator for more than 10 years, he knows the Institute extremely well and is in a unique position to lead it during this period of accelerating discovery in the biological sciences and in medicine. "In addition, he is a wonderful teacher who has repeatedly carved out time to teach undergraduates at the University of Colorado. He will bring the same thoughtful dedication to the Hughes Institute’s grants program, which focuses upon science education," she said.

6. Cech, Thomas Robert cech, thomas Robert. (b. Dec. 8, 1947, Chicago, Ill., US), American biochemist andmolecular biologist who, with Sidney Altman, was awarded the 1989 nobel Prize http://www.britannica.com/nobel/micro/111_54.html

Cech, Thomas Robert (b. Dec. 8, 1947, Chicago, Ill., U.S.), American biochemist and molecular biologist who, with Sidney Altman , was awarded the 1989 Nobel Prize for Chemistry for their discoveries concerning RNA (ribonucleic acid). Cech attended Grinnell College in Grinnell, Iowa (B.A., 1970), and the University of California at Berkeley (Ph.D., 1975, in chemistry). After serving as a National Cancer Institute fellow at the Massachusetts Institute of Technology (1975-77), he joined the Department of Chemistry at the University of Colorado in 1978, becoming a full professor in 1983. Concurrently he was an investigator for the National Institutes of Health from 1978 and for the Howard Hughes Medical Institute from 1988. Cech and Altman received a Nobel Prize for their independent discoveries that RNA, traditionally considered to be only a passive messenger of genetic information, can also take on an enzymatic role in which it catalyzes, or facilitates, intracellular chemical reactions essential to life. Before their discoveries, enzymatic activity had been attributed exclusively to proteins. Cech was the first person to show that an RNA molecule could catalyze a chemical reaction, and he published his findings in 1982. Altman, whose earlier research had pointed strongly to such a conclusion, conclusively demonstrated such enzymatic activity by an RNA molecule in 1983.

7. Encyclopædia Britannica Altman, Sidney CanadianAmerican molecular biologist who, with thomas R. cech, receivedthe 1989 nobel Prize for Chemistry for their discoveries concerning RNA http://www.britannica.com/search?query=sidney altman&seo

8. Cech, Thomas R. ,cech thomas R. (1947 Because of my research group's discoveries, more than a dozennational and international awards preceded the nobel Prize for Chemistry in http://www.cartage.org.lb/en/themes/Biographies/MainBiographies/C/Cech/Cech.htm

Cech Thomas R. Grandfather Josef, a shoemaker, immigrated to the U.S. from Bohemia in 1913. My other grandparents, also of Czech origin, were first-generation Americans. My father was and is a physician, my mother the homemaker. I was born in Chicago on December 8, 1947. The safe streets and good schools of Iowa City, Iowa provided the backdrop for the childhood years of my sister Barbara,my brother Richard and myself. My father, who loved physics as much as medicine, interjected a scientific approach and point of view into most every family discussion. I discovered science for myself in fourth grade, collecting rocks and minerals and worrying about how they were formed. By the time I was in junior high school, I would knock on Geology professors' doors at the University of Iowa, asking to see models of crystal structures and to discuss meteorites and fossils. In 1966 I entered Grinnell College, where I was to derive as much enjoyment studying Homer's Odyssey

9. Nobel Laureates In Chemistry By Alphabetical Order Themes Science Chemistry About Chemistry Generalities nobel Laureates inChemistry by Alphabetical order. Name, Calvin, Melvin, 1961. cech, thomas R. 1989. http://www.cartage.org.lb/en/themes/Sciences/Chemistry/Aboutchemistry/AlphaNobel

Themes Science Chemistry About Chemistry Generalities Name Year Awarded Alder, Kurt Altman, Sidney Anfinsen, Christian B. Arrhenius, Svante August Aston, Francis William Baeyer, Johann Friedrich Wilhelm Adolf Von Barton, Sir Derek H. R. Berg, Paul Bergius, Friedrich Bosch, Carl Boyer, Paul D. Brown, Herbert C. Buchner, Eduard Butenandt, Adolf Friedrich Johann Calvin, Melvin Cech, Thomas R. Corey, Elias James Cornforth, Sir John Warcup Cram, Donald J. Crutzen, Paul Curie, Marie Curl, Robert F., Jr. Debye, Petrus Josephus Wilhelmus De Hevesy, George Deisenhofer, Johann Diels, Otto Paul Hermann Eigen, Manfred Ernst, Richard R. Euler-chelpin, Hans Karl August Simon Von Fischer, Ernst Otto Fischer, Hans Fischer, Hermann Emil Flory, Paul J. Fukui, Kenichi Giauque, William Francis Gilbert, Walter Grignard, Victor Haber, Fritz Hahn, Otto Harden, Sir Arthur Hassel, Odd Hauptman, Herbert A. Haworth, Sir Walter Norman Heeger, Alan J. Herschbach, Dudley R. Herzberg, Gerhard Heyrovsky, Jaroslav Hinshelwood, Sir Cyril Norman Hodgkin, Dorothy Crowfoot Hoff, Jacobus Henricus Van't

10. Nature Publishing Group thomas R. cech. Always ready with examples to back up his words, cech mentions Susumu atthe Massachusetts Institute of Technology, who won the nobel Prize for http://www.nature.com/cgi-taf/DynaPage.taf?file=/nm/journal/v7/n2/full/nm0201_14

11. Nobel Prize Winning Chemists nobel Prize Winning Chemists. 1988 1990 thomas R. cech. The nobel PrizeIn Chemistry 1989. thomas R. cech was born in Chicago on December 8, 1947. http://www.sanbenito.k12.tx.us/district/webpages2002/judymedrano/Nobel Winners/t

Nobel Prize Winning Chemists Thomas R. Cech The Nobel Prize In Chemistry 1989 In Berkeley, 1970, his thesis advisor, John Hearst, had an enthusiasm for chromosome structure and function that proved infectious. In 1975 they obtained their Ph. D.'s and moved to postdoctoral positions in Cambridge, Massachusetts. Among his awards were the Pfizer Award in Enzyme Chemistry, the Award in Molecular Biology, the Heineken Prize and the Lasker Award. He was awarded the Nobel Prize jointly with Sidney Altman "for their discovery of catalytic properties of RNA." More recently, his life has been transformed by the addition to his family of two energetic daughters, Allison (born 1982) and Jennifer (1986). Because of his research group's discoveries, more than a dozen national and international awards preceded the Nobel Prize for Chemistry in 1989. Back To Main Page

12. Thomas R. Cech Heineken Prize, 1988; nobel Prize in Chemistry, 1989; National Medal RNA was longthought to function solely as a the work carried out by Professor cech and his http://www.colorado.edu/chemistry/faculty/Cech/

Awards, Prizes and Affiliations President, Howard Hughes Medical Institute USPHS Research Career Development Award, 1980 Pfizer Award in Enzyme Chemistry, 1985 Guggenheim Fellow, 1985 American Cancer Society Lifetime Research Professor, 1986 U.S. Steel Award in Molecular Biology, 1987 Member, National Academy of Sciences, 1987 Heineken Prize, 1988 Nobel Prize in Chemistry, 1989 National Medal of Science, 1995 RNA Catalysis and the Replication of Chromosome Telomeres R NA was long thought to function solely as a genetic messenger, as a component of the ribosome, and as a carrier of amino acids. Now, largely because of research done at the University of Colorado, it is just as common to think of RNA participating actively in cellular metabolism. RNA can engage in intramolecular catalysis, including self-splicing, and in some cases can act as an enzyme. A major goal of the work carried out by Professor Cech and his research group is to understand mechanisms of RNA catalysis at both the chemical and the biological levels. The work integrates organic and physical chemistry, enzymology, molecular biology, structural biology, and genetics. Current efforts focus on the structural biology of large catalytic RNAs, or ribozymes. Crystallographers in the Cech laboratory have grown x-ray diffraction-quality crystals of an active group I ribozyme (247 nt) and solved its structure at modest resolution (5 angstroms). Current work is directed toward obtaining atomic-resolution structures of active group I introns.

13. Thomas Cech Wins Nobel Prize While At MIT For BUSA Lecture Shortly before thomas R. cech was to give yesterday's lecture for the Biology UndergraduateStudent Association, the nobel committee in Stockholm announced http://www-tech.mit.edu/V109/N42/cech.42n.html

Thomas Cech wins Nobel Prize while at MIT for BUSA lecture By Annabelle Boyd Shortly before Thomas R. Cech was to give yesterday's lecture for the Biology Undergraduate Student Association, the Nobel committee in Stockholm announced that he had won this year's Nobel Prize for Chemistry. Cech will share the prize with Yale Professor Sidney Altman '60. Cech, a chemistry professor at the University of Colorado at Boulder, worked at MIT as a post-doctoral fellow under Professor Mary Lou Pardue before moving to his post in Colorado. Cech was alone when he received the phone call from the Nobel committee at 9 am yesterday morning in his hotel room. He is the winner of several major awards, including the prestigious Lasker Award for medical research, which he shared with MIT professor Phillip A. Sharp last year. To acknowledge the prize, Cech held a 25 minute press conference at the Whitehead Institute for Biomedical Research yesterday that started at noon. When asked by a reporter if the Nobel Prize would change his life, Cech replied, "I hope not." Another reporter asked if Cech had expected to win the prize. Cech answered, "I'd be home in Colorado if I knew I was going to get the call." Because of the announcement

14. Chemical & Engineering News: SCIENCE/TECHNOLOGY - THOMAS R. CECH A few minutes after the scheduled hour, thomas R. cech comes Although cech isn'treferring to his own and biomedical researcherincluding a nobel Prize in http://pubs.acs.org/cen/coverstory/7827/7827scit1.html

Home This Week's Contents Classified Ads Related Stories New crop of Howard Hughes investigators Getting A Look At Catalytic RNAs Related Organization Howard Hughes Medical Institute (HHMI) Related Person Thomas R. Cech E-mail this article to a friend Print this article E-mail the editor ... Chemcyclopedia Back Issues How to Subscribe Electronic Reader Service E-mail webmaster SCIENCE/TECHNOLOGY July 3, Volume 78, Number 27 CENEAR 78 27 pp. ISSN 0009-2347 [Previous Story] [Next Story] THOMAS R. CECH Taking The Helm At Howard Hughes Medical Institute Rebecca L. Rawls [Photo by Paul Fetters] A few minutes after the scheduled hour, Thomas R. Cech comes quickly out of his well-appointed office in the handsome complex of buildings in Chevy Chase, Md., that is the headquarters of the Howard Hughes Medical Institute (HHMI) . Gracious and informal, Cech nevertheless gives the impression of a busy man. No doubt he is. Since last January, when he became president of HHMI, the 52-year-old chemist has been jetting back and forth roughly every other week between this post and the University of Colorado , Boulder, where he continues to head his world-renowned biochemistry laboratory.

15. Remarks By Thomas R. Cech Biology's Revolution Opportunities and Challenges for Universities thomas R. CechPresident, Howard of talking about the work that led to the nobel Prize, I http://www.aau.edu/aau/Cech10.00.html

From: Research Universities and the Academic Disciplines AAU Centennial Meeting October 16, 2000 University of Chicago "Biology's Revolution: Opportunities and Challenges for Universities" Thomas R. Cech President, Howard Hughes Medical Institute Good morning. It is a special pleasure to be back in Chicago, the city where I was born, and at the University of Chicago, where I have enjoyed many fine events through the years and have many colleagues. In fact, two former students from my laboratory became tenured faculty members here at the university. It is also a thrill for me to be able to talk about the future of education and research at universities with the people who are guiding these great institutions in the twenty-first century. We are already into this century, of course, but we still have ninety-nine years to make good on whatever we decide to do. Our invitation requested that we each talk about the past, present, and future of our own research disciplines. I was asked to speak before I had become president of the Howard Hughes Medical Institute, so I planned to give you a view "from the trenches," drawing on my twentythree years of carrying out research, teaching general chemistry and biochemistry to undergraduates, and teaching graduate students at the University of Colorado at Boulder. Now, having taken on the Howard Hughes position, I feel inclined also to address some higher-level issues. So this is going to be a discussion of what biological research is like and how it is changing, mixed in with a look at some of the ways that institutions might respond to new challenges.

16. MIT Nobel Prize Winners news release, October 12, 2001; Theses of MIT Alumni nobel Prize Winners Sidney Altman,Chemistry, MIT SB 1960, shared with thomas R. cech, MIT postdoctoral http://web.mit.edu/newsoffice/nr/nobels.html

Special Reports News Releases Search MIT News Office ... MIT 56 MIT-related Nobel Prize winners include faculty, researchers, alumni and staff UPDATED OCTOBER 7, 2002 Contact Information Fifty-six current or former members of the MIT community have won the Nobel Prize . They include 22 professors, 23 alumni (including three of the professors), 13 researchers and one staff physician. Twenty-five of the Nobel Prizes are in physics, ten in chemistry, eleven in economics, eight in medicine/physiology, and two in peace. Eight Nobel prizes were won by researchers who helped develop radar at the MIT Radiation Laboratory. Nobelists who are current members of the MIT community are Drs. Horvitz (2002), Ketterle (2001), Molina (1995), Sharp (1993), Friedman (1990), Tonegawa (1987), Solow (1987), Modigliani (1985), Ting (1976) Samuelson (1970), and Khorana (1968). - MIT news release, October 7, 2002 Eight from MIT win 2001 Nobels i n 5 fields - MIT news release, October 12, 2001 Theses of MIT Alumni Nobel Prize Winners - MIT Libraries MIT-related Nobelists by discipline MIT-related Nobelists by MIT relationship H. Robert Horvitz

17. Awards And Honors: Nobel Prize 3 cech, thomas R. shared Chemistry, 1989; thomas, E. Donnall - shared Medicine/Physiology,1990; Wilkinson, Geoffrey (deceased) - shared Chemistry, 1973. nobel http://web.mit.edu/ir/pop/awards/nobel.shtml

P OPULATION A WARDS AND ... ONORS O FFICE OF THE P ROVOST Provost Home Institutional Research Awards and Honors American Academy of Arts and Sciences American Association for the Advancement of Science CAREER Award John Bates Clark Medal Crafoord Prize Dirac Medal Franklin Institute Awards Fulbright Scholars Program Gairdner Award Gregori Aminoff Prize Guggenheim Fellows HHMI Investigators Institute of Medicine Japan Prize Kyoto Prize Lemelson-MIT Awards MacArthur Fellows NAE NAS National Book Award National Medal of Science National Medal of Technology Nobel Prize Pulitzer Prize Alan T. Waterman Award -Student Honors- Fulbright Fellows Marshall Scholars Rhodes Scholars -MIT Only- Levitan Prize Nobel Prize Nobel Foundation Royal Swedish Academy of Sciences Current faculty: 7 Friedman, Jerome I. - shared Physics, 1990 Horvitz, H. Robert - shared Medicine/Physiology, 2002 Ketterle, Wolfgang - shared Physics, 2001 Molina, Mario J. - shared Chemistry, 1995 Sharp, Phillip A. - shared Medicine/Physiology, 1993

18. ALPHABETICAL LISTING OF NOBEL PRIZE LAUREATES IN CHEMISTRY ALPHABETICAL LISTING OF nobel PRIZE LAUREATES IN CHEMISTRY. Name, Year Awarded. Alder,Kurt, 1950. Calvin, Melvin, 1961. cech, thomas R. 1989. Corey, Elias James, 1990. http://www.bioscience.org/urllists/nobelc.htm

FRONTIERS IN BIOSCIENCE; ALPHABETICAL LISTING OF NOBEL PRIZE LAUREATES IN CHEMISTRY, PHYSIOLOGY AND MEDICINE ALPHABETICAL LISTING OF NOBEL PRIZE LAUREATES IN CHEMISTRY Name Year Awarded Alder, Kurt Altman, Sidney Anfinsen, Christian B. Arrhenius, Svante August ... Zsigmondy, Richard Adolf ALPHABETICAL LISTING OF NOBEL PRIZE LAUREATES IN PHYSIOLOGY AND MEDICINE Name Year Awarded Adrian, Lord Edgar Douglas Arber, Werner Axelrod, Julius Baltimore, David ... Zinkernagel, Rolf M. Source: The Nobel Prize Internet Archive

19. Thomas Cech Dr. thomas R. cech of the University of Colorado received the nobel Prize for Chemistryin 1989 for his research in establishing a link between RNA and the http://www.cualum.org/heritage/virtual_tour/cech.html

Hall of Alumni Wurlitzer Glenn Miller Thomas Cech ... Derbur Atler Thomas Cech Distinguished Professor and Investigator Department of Molecular, Cellular, and Developmental Biology University of Colorado, Boulder Dr. Thomas R. Cech of the University of Colorado received the Nobel Prize for Chemistry in 1989 for his research in establishing a link between RNA and the evolutionary chain. His discoveries have shed new light on the mystery of the beginning of life and guided genetic engineers in their search for life-saving cures in the battle against cancer. Prior to Cech's RNA breakthroughs in the early 1980s, scientists believed DNA served as the warehouse of genetic information, that RNA decoded the information and that proteins used the information to create physical attributes such as skin, hair and eyes. These proteins were thought to be the only catalysts in determining cell development. Cech's research established that RNA, like a protein, can act as a catalyst in cellular processes.

20. Biographies: Winners Of The Nobel Prize In Chemistry History of Science History of Chemistry Winners of the nobel Prize in Calvin,Melvin; cech, thomas R. Corey, Elias James; Cornforth, John Warcup; Cram, Donald http://www.infochembio.ethz.ch/links/en/history_chem_nobel_bio.html

Deutsch Links Libraries Publishers Database producers Database hosts ... Organisations Search this website: Website Index Subject Index Impressum Chemistry, Biology and related disciplines in the WWW Biographies: Winners of the Nobel Prize in Chemistry Home Links History of Science History of Chemistry ... Zsigmondy, Richard Adolf

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