61. Von Willebrand's Disease von willebrand's Disease, Pathophysiology von willebrand factor mediatesplatelet adhesion; vWF Deficiency results in mucocutaneous bleeding. http://www.fpnotebook.com/HEM17.htm

Home About Links Index ... Editor's Choice Paid Advertisement (click above). Please see the privacy statement Hematology and Oncology Coagulopathy Assorted Pages Coagulation Bleeding Disorders Dysfibrinogenemia Hemophilia A Factor IX Deficiency ... Perioperative Anticoagulation Von Willebrand's Disease Book Home Page Cardiovascular Medicine Dental Dermatology Emergency Medicine Endocrinology Gastroenterology General Medicine Geriatric Medicine Gynecology Hematology and Oncology HIV Infectious Disease Jokes Laboratory Neonatology Nephrology Neurology Obstetrics Ophthalmology Orthopedics Otolaryngology Pediatrics Pharmacology Prevention Psychiatry Pulmonology Radiology Rheumatology Sports Medicine Surgery Urology Chapter Hematology and Oncology Index Anemia Cancer Coagulopathy Cardiovascular Medicine Dermatology Endocrinology Otolaryngology Examination Gastroenterology Hematology and Oncology Hemoglobin Hemolysis Histiocytosis HIV Infectious Disease Laboratory Leukemia General Pulmonology Lymph Marrow Neurology Obstetrics Orthopedics Pediatrics Pharmacology Platelet Prevention Procedure Psychiatry Rheumatology Surgery Symptom Evaluation Vascular Page Coagulopathy Index Bleeding Bleeding Dysfibrinogenemia Bleeding Hemophilia A Bleeding Hemophilia B Bleeding Von Willebrands Clotting Pathway Background Clotting Pathway Common Clotting Pathway Extrinsic Clotting Pathway Inhibition Clotting Pathway Intrinsic DIC Hypercoagulable Hypercoagulable Antithrombin III Hypercoagulable APC resistance Hypercoagulable Fibrinolysis Hypercoagulable Protein C-S Epidemiology

62. Von Willebrand Disease - Mesa Veterinary Hospital von willebrand Disease by Dr. Lisa Croteau, DVM. Diagnosis of von willebranddisease is accomplished by a test to measure vWF levels in the blood. http://www.mesavet.com/library/vonwillebranddisease.htm

von Willebrand Disease by Dr. Lisa Croteau, DVM It is the most common bleeding disorder in dogs and is especially common in Dobermans, but also seen in Scottish terriers, Shetland sheepdogs, German shepherds, golden retrievers, and other breeds. Clinical signs vary from case to case. Signs may include bleeding from the nose, excess bleeding in intact females in heat, excess bleeding after having puppies, blood in the urine or stool, bleeding from the gums, lameness, or excess bleeding after surgical procedures or if nails are trimmed too short. Diagnosis of von Willebrand disease is accomplished by a test to measure vWF levels in the blood. Genetic tests also exist for Dobermans, Scottish terriers, Shetland sheepdogs, Manchester terriers, poodles, and Pembroke Welsh corgis which can identify them as being affected by the disease, carriers of the condition, or free of the gene. DNA for these tests is obtained from a swab of the inside of the cheek. Treatment of von Willebrand disease is blood or plasma transfusions to supply vWF during episodes of bleeding.

63. BBC Health - Ask The Doctor - Von Willebrand Disease Ask the Doctor. Q. von willebrand's disease. What is von willebrand'sdisease and how is it treated? Naomi. Dr Trisha Macnair responds. http://www.bbc.co.uk/health/ask_doctor/vonwillebrand.shtml

CATEGORIES TV RADIO COMMUNICATE ... INDEX SEARCH MONDAY 31st March 2003 Text only BBC Homepage Health Homepage Ask the Doctor ... Help Like this page? Send it to a friend! Ask the Doctor Q. Von Willebrand's disease What is Von Willebrand's disease and how is it treated? Naomi Dr Trisha Macnair responds Von Willebrand disease is an inherited disorder of the blood which leads to abnormal bleeding. Unlike other bleeding disorders such as haemophilia, Von Willebrand disease can affect both men and women - in fact it is the commonest bleeding disorder and about 1 in 100 women have it. It's not actually one condition but a group of similar diseases all caused by a problem with one particular protein in the blood (known as Von Willebrand factor or VWF) which plays an essential part in clotting by helping tiny cells called platelets to stick to the walls of a damaged blood vessel. VWF also has another important job, carrying another clotting chemical called Factor VIII around in the blood. So if levels of VWF are low or it doesn't work properly there is abnormal bleeding. Three types Symptoms of Von Willebrand Disease Easy bruising Frequent nose bleeds.

64. What Is Von Willebrand Disease? health care. The Discovery of von willebrand Disease. I can remember firstdescribed the unusual symptoms. Who Has von willebrand Disease? http://www.kelleycom.com/pen_vonwill.htm

65. Resources For People With Von Willebrand Disease Resources for people with von willebrand disease. The Parent Exchange Newsletter August 2001 © LA Kelley Communications, 2001. What is von willebrand Disease? http://www.kelleycom.com/pen_res_consume.htm

66. Von Willebrand Disease Cardiovascular Health. von willebrand Disease. von willebrand disease is a typeof bleeding disorder. von willebrand Disease What is von willebrand disease? http://jhhs.client.web-health.com/web-health/topics/GeneralHealth/generalhealths

67. Doença De Von Willebrand Translate this page do tecnicismo. José Carlos Pereira. DOENÇA DE von willebrand. O sangue DOENÇADE von willebrand (DVW). É uma doença hereditária http://www.nossoscaesegatos.hpg.ig.com.br/dvw.htm

NÚCLEO DE CRUZEIRO DA SOCIEDADE PAULISTA CES PASTORES ALEMES BOLETIM DA DIRETORIA DE CRIAÇO NÚMERO 81 JUNHO 2000 DIRETOR DE CRIAÇO: DR. JOSÉ CARLOS PEREIRA R. JOAQUIM DO PRADO, 49, CRUZEIRO SP, CEP 12700-000 TEFAX 0xx125443590, MAIL Drjosecarlos2000@aol.com PS Alguns números do nosso boletim, por sua abrangência técnica, não são bem entendidos por criadores não profissionais veterinários ou médicos. Vale a pena editá-los com muito tecnicismo? Creio que sim. Embora algumas vezes não muito entendidos, levam o criador a tomar conhecimento do desenvolvimento técnico-científico de problemas que envolvem os nossos animais. A literatura brasileira é pobre e, muitas vezes, muito superficial. Como a literatura estrangeira está muito desenvolvida, os criadores tomam conhecimento de trabalhos muito técnicos que possibilitam o desenvolvimento da criação. Se ficarmos na superficialidade, arranhando somente os problemas, jamais acompanharemos o que acontece no exterior. É só compararmos como estamos cada vez mais atrasados em relação aos alemães e aos norte-americanos no controle de doenças hereditárias como a displasia coxo-femural. E o abismo que nos separa na criação, tanto dos animais ditos de estrutura como naqueles de trabalho. Procuro escrever os boletins após exaustiva pesquisa feita pela exigência de atualização da minha profissão de médico. Com algumas pitadas do que acompanho na criação pastoreira alemã como sócio da SV há muitos anos. Assim, pelo menos procuro colocar nas mãos dos amigos criadores matérias atualizadas, embora algumas vezes da leitura dificultada pela exigência do tecnicismo.

68. Immunolex ApS: Von Willebrand Factor, Alpha Fetoprotein. Immunolex ApS, von willebrand factor. of antibodies and antigens Please contactus and we von willebrand factor will send you an offer without obligation. http://www.antibodyshop-guide.com/searchnps/von_willebrand_factor.html

Immunolex ApS, von willebrand factor. Biotech company specialized in immunoassays, immunodiagnostics and antibody production e.g. elisa kits and monoclonal and polyclonal antibodies [von willebrand factor] [amyloid beta peptide] [alpha fetoprotein] [apolipoprotein] ... [sitemap] Print IMMUNOLEX is a new biotechnology company whose sales and marketing division for immunological products is called AntibodyShop. All the immunological products and services offered through this platform are produced in co-operation with Statens Serum Institut (SSI), Copenhagen, Denmark. SSI has nearly 100 years of experience in the production of antibodies SSI is von willebrand factor the national Center for the prevention and control of infectious diseases and congenital disorders in Denmark. The Institut was founded in 1902 to produce diphtheria antitoxin from horse serum and rapidly gained xzyqnpsvon willebrand factor worldwide recognition for its contribution to immunization research and a reputation as a manufacturer of high-quality products. Increasing international activity with export to 80 von willebrand factor countries in all five continents has allowed SSI to expand. Today SSI is one of Northern Europe's largest research centers in immunology and microbiology - the two core areas on which SSI's activities are based. SSI also produces a wide range of monoclonal antibodies and a variety of blood and other products from several animal species.

69. PetPlace.com - Article: Von Willebrand’s Disease (VWD) von willebrand’s Disease (VWD), by Dr. Leah Cohn. Next Page, (Information Indepth). VonWillebrand’s disease can cause prolonged or excessive bleeding. http://petplace.netscape.com/articles/artShow.asp?artID=55

70. The Contact A Family Directory - HAEMOPHILIA, VON WILLEBRAND SYNDROME And Other printer friendly, HAEMOPHILIA, von willebrandSYNDROME and other coagulation defects, http://www.cafamily.org.uk/Direct/h18.html

printer friendly HAEMOPHILIA, VON WILLEBRAND SYNDROME and other coagulation defects home more about us in your area conditions information ... how you can help search this site The conditions covered in this entry are haemophilia A, haemophilia B (Christmas disease), von Willebrand disease and some other coagulation defects. The haemophilias are a group of inheritable blood disorders characterised by various defects in the blood clotting system. The clotting factors present in blood were initially known by Roman numerals, numbered from I to XIII. More recently described factors have been given names and some deficiencies are associated with excessive, rather than reduced, blood coagulation. Factor VIII is deficient in classical haemophilia, also known as haemophilia A. Factor IX is deficient in haemophilia B (also known as Christmas disease). Von Willebrand factor is deficient in von Willebrand disease and this results in a failure of platelet and vessel wall function with an associated reduction in factor VIII. In haemophilia A and B it is almost always males who are affected, with haemophilia A being five times as frequent as haemophilia B. Thus there are currently about 5,000 people with haemophilia A and 1,000 people with haemophilia B in the UK. Von Willebrand disease occurs equally in males and females and about 5,000 patients are registered in the UK but the real number of affected people is almost certainly but much greater. These conditions affect all racial groups and occur worldwide.

71. Von Willebrand's Disease Canine von willebrand's Disease (vWD). Cause The bleeding tendency of vWDis caused by a deficiency of von willebrand factor protein (vWF). http://www.angelfire.com/nc/meisenhaus/vwd.html

Canine von Willebrand's Disease (vWD) Von Willebrand's disease is a bleeding disorder caused by a defect in a blood protein required for normal clotting and control of hemorrhage. This disease occurs with varying frequency in many different breeds of dog (including the Drahthaar), as well as other domestic animals and human beings. In the same manner as for hip dysplasia, Verein Deutsch Drahthaar (VDD/GNA) has instituted a "voluntary" testing program. The purpose being: to identify and track affected individuals and to assist Cornell University's Comparative Hematology Section in developing a database to help better understand the genetic behavior of the disease. Cause...The bleeding tendency of vWD is caused by a deficiency of von Willebrand factor protein (vWF). This blood protein is involved in the first phase of blood vessel repair, and is distinct from coagulation factors. Inheritance...The gene for vWF is carried on an autosome and both males and females have two genes for this protein, one inherited from dam and one from sire. Expression and Transmission...In most breeds, the presence of one abnormal gene is sufficient to cause a bleeding tendency in some individuals. This inheritance pattern is called autosomal incompletely dominant. In a few breeds (Scottish terrier, German wirehair, and Chesapeake retriever) individuals with one normal and one abnormal gene are asymptomatic carriers and all affected individuals have two abnormal genes. This pattern is autosomal recessive.

72. Gradipore Von Willebrand ELISA Assay Rainbow Scientific logo. Products Gradipore von willebrand Assay. vonWillebrand Disease. von willebrand Factor Antigen / Collagen Binding Assay. http://www.rainbowscientific.com/g-vonwillebrand.html

Products Gradipore von Willebrand Disease von Willebrand Factor (vWF) is an important blood clotting protein involved in both assisting platelet adhesion and stabilization of clotting factor VIII. In von Willebrand Disease (vWD), there is either a partial quantitative deficiency or shortage of vWF (classified as vWD Type 1) or a qualitative or functional deficiencey (classified as vWD Type 2). vWD Type 3 is rare and charachterized by virtually complete deficiency of vWF. The incidence of vWD worldwide is estimated at 1% to 3% but may be more common since mild cases may remain undetected. Historically, a wide variety of assays have been used to characterize vWF. Currently the most common methods are vWF:AG assay by Laurell rocket electrophoreses, ELISA or Latex Immunoassay and Ristocetin Cofactor agglutination (RiCoF) or Ristocetin induced platelet aggregation (RIPA).

73. 1Up Health > Von Willebrand's Disease > Causes, Incidence, And Risk Factors Of V Comprehesive information on von willebrand's disease . 1Up Health Diseases Conditions von willebrand's disease Causes, Incidence, and Risk Factors. http://www.1uphealth.com/health/von_willebrands_disease_info.html

1Up Health Von Willebrand's disease Alternative Medicine Clinical Trials ... Health Topics A-Z Search 1Up Health Von Willebrand's disease Information Von Willebrand's disease Causes, Incidence, and Risk Factors Definition : Von Willebrand's disease is a hereditary bleeding disorder caused by a deficiency of von Willebrand factor. Von Willebrand factor helps platelets to stick to the blood vessel wall and to each other, which is necessary for normal blood clotting. Causes, Incidence, and Risk Factors Von Willebrand's disease is the most common hereditary bleeding disorder. It affects both sexes approximately equally. Most cases are mild, and bleeding may occur after a surgical procedure or tooth extraction. The condition is worsened by the use of aspirin and other nonsteroidal anti-inflammatory drugs (NSAIDs). Bleeding may decrease during pregnancy The disease is very common, affecting at least 1% of the population. There are no racial or ethnic associations with this disorder. A family history of a bleeding disorder is the primary risk factor.

74. Von Willebrand's Disease There has been considerable discussion about von willebrand's Disease(vWD) in Berners over the last two years. Very recent developments http://www.bmd.org/health/vonwillebrands.html

Summary Club Contacts Buyers Guide Calendar of Events ... Breed Standard Von Willebrand's Disease in Bernese Mountain Dogs Running with Berners Cancer Histiocytosis Veterinary Glossary ... Von Willebrand's Disease There has been considerable discussion about von Willebrand's Disease (vWD) in Berners over the last two years. Very recent developments now give Berner owners and breeders the opportunity to evaluate their dogs and with prudent breeding practices eliminate this disease from our breed. VetGen has recently developed a DNA test for vWD in Berners. This test is identical to the test for Doberman Pinschers. A great deal of thanks goes to Cindy Stauch for serving as the vital laison between VetGen and dog owners. We also need to thank VetGen for doing this study on 30-50 dogs free of charge to determine if vWD in Berners has a mutation that is already known in another breed. The owners of the dogs that submitted samples to VetGen need to be thanked. We as a breed fancy should be mindful of how lucky we are. If vWD in Berners was not due to one of the known mutations it would have cost us literally hundreds of thousands of dollars to find the mutation. There are already a few breeds that are not so lucky. A little background is in order. There are three types of vWD, based on DNA mutations, so far found in dogs. Type I is autosomal recessive and the one seen in Doberman Pinschers as well as Manchester Terriers, Poodles, and Pembroke Welsh Corgis. It is a relatively mild disease with infrequent spontaneous bleeds and will be discussed in more detail. Type II is found in German Shorthaired and Wirehaired Pointers. Type III is a mutation that stops production of the von Willebrand's Factor (vWF) completely. This type is seen in Scottish Terriers and Shetland Sheepdogs and is severe, often resulting in spontaneous bleeds and death in puppyhood for affected dogs. Of note is that the mutation for these two breeds is different in the Type III disease but both result is no vWF production. This is important because the test for Scottish Terriers won't work on Shetland Sheepdogs.

75. LocusLink Report Similar pages Mutations in the region encoding the von willebrand factor A Click here to read Mutations in the region encoding the von willebrand factorA domain of matrilin3 are associated with multiple epiphyseal dysplasia. http://www.ncbi.nlm.nih.gov/LocusLink/LocRpt.cgi?l=7450

76. Ziekte Van Von Willebrand LITERATUUR, — Beginpagina — Ziekten en aandoeningen — Ziekte vanvon willebrand Ziekte van von willebrand Synoniem Pseudohemofilie. http://www.erfocentrum.nl/zena/wille.php

erfelijkheid.nl winkel mail ons nieuwsbrief ... sitemap ZIEKTEN EN AANDOENINGEN ERFELIJKHEID LITERATUUR (PARA)MEDICI Beginpagina ... Ziekten en aandoeningen Ziekte van Von Willebrand Ziekte van Von Willebrand Synoniem Pseudo-hemofilie Korte beschrijving Bij de ziekte van von Willebrand is er sprake van een verhoogde bloedingneiging door een gestoorde functie van zowel de bloedplaatjes als van een bepaalde stollingseiwit in het bloed (de Von-Willebrandfactor). Meestal gaat het om een erfelijke aandoening, in enkele gevallen ontstaat een niet-erfelijke vorm als gevolg van een bepaalde auto-immuunziekte. Diagnose De diagnose wordt gesteld door middel van bloedonderzoek waarbij men kijkt naar een verlengde bloedingstijd en de activiteit van de stollingsfactoren. Symptomen Doorgaans zijn de verschijnselen vrij mild zoals het gemakkelijk oplopen van blauwe plekken en eventueel lichte bloedingen van vooral slijmvliezen en maag-darmstelsel. In zeldzame gevallen kunnen wel ernstige bloedingen voorkomen. Er is vaak een voorgeschiedenis van veel neusbloedingen in de jeugd, nabloeden uit kleine snijwonden, overvloedig bloedverlies bij menstruatie, door blijven sijpelen na mond- of kleine gynaecologische operaties en het gemakkelijk oplopen van blauwe plekken. Behandeling Bij ernstige bloedingen kan de patiënt worden behandeld met DDAVP, een analoog van vasopressine (een vaatvernauwer), dat een tijdelijke stijging van de concentratie van de von Willebrandfactor teweegbrengt. Cryoprecipitaat bevat eveneens von Willebrandfactor en kan net als DDAVP bij de behandeling worden gebruikt.

77. Canine Von Willebrand's Disease Canine von willebrand's disease. von willebrand’s isn’t so much a diseaseas a condition. von willebrand’s affects Factor 8 on this tree. http://coco.essortment.com/vonwillebrands_rlig.htm

Canine Von Willebrand's disease Von Willebrand’s isn’t so much a disease as a condition. Of all the inherited bleeding disorders in animals (and humans) it is the most common. The defect isn’t autosomal (sex linked) so both males and females can suffer from the “disease.” It must be remembered that just because a dog doesn’t show symptoms of von Willebrand’s, it doesn’t mean it can’t be a carrier. Von Willebrand’s was discovered in humans and called a “disease” in the 1920s by a Finnish doctor coincidentally named, von Willebrand. After further research, he was able to figure out the illness was actually linked to a missing factor in the blood’s clotting ability. bodyOffer(32256) Modern research has found von Willebrand’s doesn’t lower the number of platelets (the factor in the blood that causes clotting) but changes the platelet’s actual make up. Researchers have discovered there are twelve “factors” that go into the platelet’s make up and allows them to work properly. They have set up a “Cascading Clotting Tree” to mark and show the different factors. Von Willebrand’s affects Factor 8 on this tree. There is a large, multimeric glycoprotein that is labeled as vWF. This glycoprotein circulates in the plasma and is required for platelet adhesion. When there is a defect in the vWF gene, there is an insufficient synthesis of the vWF glycoprotein. This insufficiency causes the platelets to fail in their adhesion or “sticking together.” Like water coming through a damn with a hole in it, the platelet “leaks” and bleeding continues.

78. Hemophilia Council Of California What is von willebrand disease? von willebrand disease (vWD) is themost common inherited bleeding disorder. This condition is named http://www.hccalif.org/vw.html

Office Locations eMail Us Educational Hemophilia von Willebrand HIV Hepatitis ... Free Video Offer About Us Who We Are Services Provided Office Locations Board Members ... Links Page InterACT! News Board Sign Guestbook View Guestbook Confidential eMail ... Submit An Article Help us by reporting any broken links you may encounter. Thank you. What is von Willebrand disease? von Willebrand disease (vWD) is the most common inherited bleeding disorder. This condition is named for the doctor, Erik von Willebrand, who first identified it in 1926. It is now known that vWD is caused by a deficient or defective blood protein called von Willebrand factor (vWF). If a person has an altered vWF protein or low levels of vWF it takes longer for the bleeding to stop. Because vWD is an inherited or genetic disorder, it affects both men and women. There are many different types which can range from mild to severe. Bleeding in persons with vWD usually involves the mucous membranes, the delicate tissues that line such body passages as the nose, mouth, uterus, vagina, stomach and the intestines Some of they symptoms of vWd are: heavy menstrual periods, excessive nosebleeds, easy bruising, heavy bleeding following dental work, surgery, injury or childbirth

79. Von Willebrand Factor Normandy von willebrand Factor Normandy. von willebrand Disease 2N. Factor VIIIis stabilized in plasma by complexing with von willebrand factor. http://www.cityofhope.org/cmdl/VWFN.asp

Genetic Testing (DNA Testing) at the Clinical Molecular Diagnostic Laboratory of the City of Hope National ... Center in Duarte, California von Willebrand Factor Normandy von Willebrand Disease 2N Factor VIII is stabilized in plasma by complexing with von Willebrand factor. Specific mutations in the factor VIII binding site of von Willebrand factor result in destabilization of this complex causing rapid removal of factor VIII from the circulation . Three mutations (T791M in exon 18 , R816W in exon 19 , and R854Q in exon 20 ) in the von Willebrand factor gene may account for a majority of the Normandy mutations. However, other mutations have been described . The phenotype of these von Willebrand factor Normandy mutations resembles mild hemophilia A showing low factor VIII levels and normal von Willebrand factor levels and multimers. The inheritance of this “pseudo” hemophilia A is autosomal recessive rather than X-linked as is the case for hemophilia A. Mutations altering factor VIII binding are detected by direct DNA sequence analysis of exons 18-20 of the von Willebrand factor gene. To open a printable assay summary in a new window, click the link below.

80. Nvhp, Nederlandse Vereniging Van Hemofilie-Patiënten WAT IS DE ZIEKTE VAN von willebrand. De ziekte van von willebrand is een erfelijkeafwijking in de bloedstolling die zowel bij mannen als bij vrouwen voorkomt. http://www.nvhp.nl/nvhp-willebrand.htm

WAT IS DE ZIEKTE VAN VON WILLEBRAND De ziekte van Von Willebrand is een erfelijke afwijking in de bloedstolling die zowel bij mannen als bij vrouwen voorkomt. De ziekte van Von Willebrand komt voornamelijk tot uiting via slijmvliesbloedingen (neus- en tandvleesbloedingen). Bij het trekken van kiezen, operaties en ongelukken bestaat er een ver­hoogd risico op nabloedingen. Bij vrouwelijke patiënten kan het leiden tot hevige bloedingen tijdens de menstruatie of na een bevalling. DE BLOEDSTOLLING Een goed verloop van de bloedstolling in het menselijk lichaam is van zeer veel factoren afhankelijk. Een van deze factoren is het voldoende aanwezig zijn van de Von Willebrand factor. De Von Willebrand factor is een speciaal eiwit dat tijdens het stollingsproces een lijmfunctie vervult. Het eiwit is nodig om de hechting van bloedplaatjes aan de vaatwand mogelijk te maken. De Von Willebrand factor zorgt verder voor het transport van factor VIII, een ander stollingseiwit. Bij mensen met een ver­laagd gehalte aan de Von Willebrand factor, zal ook het factor VIII gehalte verlaagd zijn. Naarmate het gehalte aan de Von Willebrand factor of factor VIII lager is, zal de ziekte ernstiger zijn. Bij ernstige vormen van de ziekte van Von Willebrand kunnen zich ook bloedingen voordoen in gewrichten, spieren en zacht weefsel. Daarmee vertoont de ziekte van Von Willebrand verwantschap met een andere afwijking in de bloedstolling, namelijk hemofilie.

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