21. Types Of Von Willebrand Disease Types of von willebrand disease. The biochemical heterogeneity of von willebranddisease became apparent in the late seventies and early eighties. http://www.lifesciences.napier.ac.uk/courses/projects99/vwillibrand/typesof.htm

Ty pes of von Willebrand disease The biochemical heterogeneity of von Willebrand disease became apparent in the late seventies and early eighties. This led to a complex mode of classification. However with continued research into the biosynthesis and function of von Willebrand Factor has led to a more simplified classification. The main three categories are based on whether the patient suffers from; a quantitative deficiency; a qualitative deficiency or a total deficiency of von Willebrand Disease. Type 2 is divided into four variants based upon details of the phenotype. There is also an acquired form of von Willebrand Disease. Classification of von Willebrand Disease TYPE DEFICIENCY QUANTITATIVE QUALITATIVE QUALITATIVE QUALITATIVE QUALITATIVE TOTAL DEFICIENCY Type 1; Type 1 von Willerband disease is the most commonest type affecting approximately 70-80% of the population. Likewise type 1 produces the mildest effects. In type 1 the distribution of multimers is normal and all molecular forms are decreased proportionally. This reduction of multimers is different in each patient and may be variable on different occasions in each patient. Diagnosis of type 1 is impaired as plasma levels of Factor VIII

22. Sheffield University VWF Homepage Genetic mutation and polymorphism database for human von willebrand factor with other useful information for researchers, from the University of Sheffield, UK. http://www.sheffield.ac.uk/vwf/

Maintained at the University of Sheffield, United Kingdom ISTH SSC VWF Information Homepage Supported by Up-to-date databases of point mutations, insertions, deletions, and polymorphisms found in the gene for human von Willebrand Factor. New! Information for patients section. Links to useful sources of information for those diagnosed with von Willebrand disease. Fast link: Mutations Polymorphisms Nomenclature VWF Sequences VWD Diagrams Useful links Database submission References Downloads Searches Sponsor Patient information Credits Please select one of the following links: Mutations Mutations in the human VWF gene sorted by nucleotide number and by association with type of von Willebrand disease (VWD) Polymorphisms Polymorphisms in the human VWF gene Nomenclature Current nomenclature recommended by the ISTH VWF SSC VWF Sequences Amino acid, cDNA and genomic DNA links with Mancuso genomic and pseudogene sequences. Also links to VWF sequences of other species VWD A brief description of the types of von Willebrand Disease (VWD) Diagrams Figures of the VWF gene, mRNA and protein (including binding domains) and example multimer gels for VWD type 2 defects

23. Von Willebrands Sygdom von willebrands sygdom er den mest almindelige arvelige bl¸dersygdom op til ©n procent af befolkningen (b¥de m¦nd og kvinder) kan have den. At have von willebrands sygdom betyder, at man ikke har nok af det protein, der hedder von willebrandfaktor, eller at proteinet er forkert bygget op. von willebrand-faktoren er med til at s¸rge for, at bl¸dninger kan stoppe. http://www.netdoktor.dk/sygdomme/fakta/vonwillebrand.htm

Sundhedscentre Astma Mave og tarm Hjerte Seksualitet Leksikon Sygdomme Medicin Symptomer Sundhed ... Vitaminer Interaktivt Nyheder Debat Test dig selv Forum Babyklub Depression Rygning Samliv ... Rejsemedicin Service Tema-overblik Patientforeninger Ventelister Vejviser Von Willebrands sygdom Af Hvad er von Willebrands sygdom? De fleste (cirka 80 procent) har sygdommen i mild grad (type 1) med symptomer som kraftige menstruationer Von Willebrands sygdom er arvelig. Sygdommen skyldes en fejl i gener kromosom Kraftig og langvarig menstruation hovedpine , svimmelhed, Hvordan behandles sygdommen P-piller I Danmark er de tre mest brugte midler til von Willebrands sygdom: desmopressin tranexamsyre faktor VIII/von Willebrand-faktor. Gentag proceduren Octostim Cyklokapron Pamol Panodil Pinex Setamol Udsigt for fremtiden Patientforening Medicin som kan anvendes: Sidst opdateret Brugerbetingelser: Vigtige juridiske informationer fortrolighedspolitik The documents contained in this web site are presented for information purposes only. The material is in no way intended to replace professional medical care or attention by a qualified practitioner. The materials in this web site cannot and should not be used as a basis for diagnosis or choice of treatment. Click here - Conditions for use - Important legal information.

24. WebMD Canada - Von Willebrand's Disease Information on definition, causes, incidence and risk factors, symptoms and signs and treatment as well as expectations, prognosis and complications. http://my.webmd.ca/content/asset/adam_disease_von_willebrands_disease

25. Treatment Of Von Willebrand Disease Most people with von willebrand Disease display very mild symptoms, unless they are suffering form type 3. http://www.biol.napier.ac.uk/courses/projects99/vwillibrand/treatmen.htm

Sy mptoms, testing and treatment Symptoms Testing Treatment Symptoms Most people with von Willebrand Disease display very mild symptoms, unless they are suffering form type 3. Many people do not realise that they are suffering from the disease until another family member is diagnosed. These symptoms are highly variable even within a family and not every sufferer displays every sign. von Willebrand disease is associated with easy bruising, recurrent nosebleeds, mucocutaneous haemorrhage and prolonged or posttraumatic bleeding. plasma von Willebrand Factor and Factor VIII levels increase during pregnancy. In patients suffering from type 3 spontaneous hemorrhage from mucous membranes and gastrointestinal tract is quite common and can be life threating. For women suffering from this type and for those people whom have just undertaken surgery bleeding is controlled by hormone replacement therapy. Sufferers are advised against competing in any sport that carries a high risk of injury. This is to prevent injury that would be followed by the above symptoms. For classification of von Willebrand disease click here back to top Testing In a clinical laboratory there are five basic phenotypic tests to diagnosis von Willebrand disease and one genetic test.

26. Hemophilia Translate this page La maladie de von willebrand La maladie de von willebrand. Introduction. Lamaladie de von willebrand. Autres déficits en facteur de coagulation. http://www.hemophilia.ca/fr/2.2.html

La maladie de Von Willebrand La maladie de Von Willebrand Introduction Les types de maladies Le diagnostic Les traitements ... Faire un don

27. Von Willebrands Disease Management And Treatment In The Home Setting Patient selfcare helps ward off complications of excessive hemorrhagic episodes in this inherited bleeding disorder. http://www.uspharmacist.com/NewLook/Ce/von/lesson.cfm

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28. WebMD/Lycos - Health Guide Comprehensive information on definition, causes, incidence and risk factors as well as symptoms, signs and tests, treatment, prognosis and complications. http://webmd.lycos.com/content/asset/adam_disease_von_willebrands_disease

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29. Von Willebrand births. The Symptoms of von willebrand Disease von willebrand com. How toget more information on von willebrand Disease Additional information http://www.hemophilianevada.org/von_Willebrand/von_willebrand.html

What is von Willebrand Disease? von Willebrand Disease is an inherited deficiency or defect of a blood clotting substance called von Willebrand factor. Its' symptoms include easy bruising, frequent nose bleeds, bleeding gums, gastrointestinal bleeding, prolonged menstrual bleeding, and excessive bleeding following surgery. Unlike hemophilia, von Willebrand Disease occurs equally amongst males and females and is much more common than hemophilia, occurring in 1 in every 50 births. The Symptoms of von Willebrand Disease: von Willebrand Disease (vWD) should be suspected in anyone who has the following symptoms: Easy bruising Heavy or prolonged menstrual bleeding Frequent or prolonged nosebleeds Prolonged bleeding after injury, surgery, childbirth, or invasive dental procedures The severity of symptoms varies from person to person. Who gets vWD? Anyone can get vWD; both males and females. It affects an estimated 1 out of every 50 people. That's millions of Americans! Where Does vWD Come From?

30. Whoops Information including Pediatric studies. http://www.beckmancoulter.com/Coulter/Techpubs/Pediatric-Profiles/vWD.asp

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31. Sheffield University VWF Homepage von willebrand Disease (VWD). VWD is a congenital bleeding disorder which resultsfrom quantitative or qualitative defects of von willebrand factor (VWF). http://www.shef.ac.uk/vwf/vwd.html

Maintained at the University of Sheffield, United Kingdom ISTH VWF SSC Information Homepage Fast link: Back to index Mutations Polymorphisms Nomenclature VWF Sequences Diagrams Useful links Database submission References Downloads Searches Sponsor Credits von Willebrand Disease (VWD) VWD is a congenital bleeding disorder which results from quantitative or qualitative defects of von Willebrand factor (VWF). It is the most common inherited bleeding disorder in humans with a prevalence ranging from 3-4 per 100,000 to 1.3% of the population (reviewed in Keeney and Cumming, 2001). More than 20 subtypes of VWD have been described, although current classification consists of 6 distinct types (Sadler, 1994). Types 1 and 3 are quantitative VWF defects whilst the four type 2 variants are qualitative VWF defects. For more information, see the review by Keeney and Cumming, 2001. For example multimer diagrams, click here Back to VWF mutations Back to index VWD Classification Description Type 1 Partial quantitative deficiency of VWF. Typically autosomal dominant in inheritance although diagnosis is complicated by reduced penitrance and variable expressivity. Characterised by parallel reductions in VWF:Ag and Factor VIII. Multimer distribution is normal. Type 2A Qualitative VWF defect associated with absence of the largest multimers and low levels of VWF:Ricof activity relative to VWF:Ag. Generally autosomal dominant, caused by missense mutations within the VWF A2 repeat. Group 1 (defect in intracellular transport) or group 2 (increase in proteolysis in plasma after secretion).

32. NHF | Bleeding Disorders Information Center | Von Willebrand Disease von willebrand Disease What Is It? von Finland. In von willebrand disease,blood platelets don't stick to holes in blood vessel walls. http://www.hemophilia.org/bdi/bdi_types3.htm

VON WILLEBRAND DISEASE Hemophilia A Hemophilia B von Willebrand Disease Factor I Deficiency Factor II Deficiency Factor V Deficiency Factor VII Deficiency Factor X Deficiency Factor XI Deficiency Factor XII Deficiency Factor XIII Deficiency Thrombophilia von Willebrand Disease What Is It? von Willebrand's disease is a hereditary deficiency or abnormality of the von Willebrand factor in the blood, a protein that affects platelet function. It's the most common hereditary disorder of platelet function, affecting both women and men. The disease is estimated to occur in 1% to 2% of the population. The disease was first described by Erik von Willebrand, a Finnish physician, who reported a new type of bleeding disorder among island people in Sweden and Finland. In von Willebrand disease, blood platelets don't stick to holes in blood vessel walls. Platelets are tiny particles in the blood that clump together at the site of an injury to prepare for the formation of a blood clot. von Willebrand factor causes them to bind to areas of a blood vessel that are damaged. If there is too little von Willebrand factor, or the factor is defective, platelets do not gather properly when a blood vessel is injured. von Willebrand factor is found in plasma, platelets, and blood vessel walls. When the factor is missing or defective, the first step in plugging a blood vessel injury (platelets adhere to the vessel wall at the site of the injury) doesn't take place. As a result, bleeding doesn't stop as quickly as it should, although it usually stops eventually.

33. NHF | HANDI | Fact Sheet On Von Willebrand Disease In Women Fact Sheet on von willebrand Disease in Women • The most common bleeding disorderin women and girls is von willebrand Disease (vWD), an inherited disorder http://www.hemophilia.org/resources/vwd.htm

RESOURCES NHF Publications HANDI HTC Directory NHF Chapter Listing ... HOME Fact Sheet on von Willebrand Disease in Women The most common bleeding disorder in women and girls is von Willebrand Disease (vWD), an inherited disorder that affects 1% to 2% of the population. vWD is caused by a defect in or a deficiency of a blood clotting protein called von Willebrand factor. vWD causes bleeding into the skin and from mucous membranes, which line the nose, gums, and the gastrointestinal and genitourinary tracts. Symptoms of vWD include: heavy menstrual periods, frequent and prolonged nosebleeds, easy bruising, bleeding gums, and prolonged bleeding following dental work or surgery. The most common presenting symptom for women with vWD is heavy and prolonged menstrual bleeding. Although this symptom is caused by a problem with the blood, it is frequently misdiagnosed as a gynecological problem by doctors who are not hematologists. Young women with vWD can have menstrual periods that last for weeks, or in some cases, for months at a time. Continuous bleeding can lead to severe anemia. Prolonged menstrual bleeding can make becoming pregnant impossible and/or can increase the risks of miscarriage. Painful menstrual periods, a sense of isolation due to not knowing that others have similar problems, and frustration with the medical system are common quality of life concerns.

34. The Other Bleeding Disorder Information on the three types of von willebrand Disease as well as treatments. http://www.haemophilia.org.za/Vonwil2.htm

The "Other" Bleeding Disorder W hat is the most common inherited bleeding disorder, the one that affects many millions of people around the world, and up to two million in the United States? You may be surprised to hear that it is not haemophilia. It is von Willebrand disease , a related disorder that few people have heard of, unless they have it or know someone who does. Why is such a common illness such a secret? Perhaps because the disease is usually less severe than haemophilia, it has not generated the kind of publicity, educational efforts and support that other chronic illnesses have. In fact, it is often so mild, it is not diagnosed at all. Some people live with the disease for many years before getting an accurate diagnosis. For more severely affected patients, this lack of knowledge has caused real suffering. Alice Arabshian, a college student was diagnosed with clinically severe von Willebrand disease when she was a year old, says of her early childhood in Cyprus where almost nothing was known about von Willebrand: "There were no facilities for people with this illness. It was virtually impossible to get proper treatment." Fortunately, substantial progress has been made in recent years. The von Willebrand gene has been identified and research is underway to develop gene therapy. As research continues, however, the challenge continues to educate healthcare professionals and the public about this disorder. That is the best way to assure those with von Willebrand that they will receive proper diagnoses and treatment.

35. Von Willebrand's Disease von willebrand's Disease by Jennie Bullock von willebrand's disease is a bleedingdisorder found in many breeds of dog as well as other animals. http://www.barkbytes.com/medical/med0036.htm

von Willebrand's Disease by Jennie Bullock von Willebrand's disease is a bleeding disorder found in many breeds of dog as well as other animals. It is characterized by hematomas, nosebleeds, and intermittent limping (due to bleeding into the joints). Similarly to hemophilia A, dogs with this disorder are deficient in clotting factor VIII activity. One of the primary distinctions of von Willebrand's disease however, is that this disorder is not sex-linked. von Willebrand's disease appears in two variations: inherited and acquired. In its acquired presentation von Willebrand's is a complication of thyroid deficiency. With proper treatment and stabilization of the dog's thyroid levels the von Willebrand's is negated. Hereditary von Willebrand's disease is far more complex. Each breed of dog will have a different set of "typical symptoms" of the disease. Symptoms can range from abnormally long bleeding time due to a cut toenail, to hemorrhaging during minor surgery, to spontaneous nosebleeds, with a wide assortment of presentations between. Injuries that are followed by bleeding may or may not require a transfusion. Even a small wound may necessitate veterinary treatment. Carriers of this disorder can live their entire lives with no outward indications of this disease. von Willebrand's disease can be fatal. There is no cure and no effective treatment. It appears that DNA screening is the most accurate means of testing currently.

36. Nursing Spectrum- Career Fitness Online von willebrand Disease. The commonly inherited bleeding disorder. Examples and treatments. http://nsweb.nursingspectrum.com/ce/ce222.htm

Susanne J. Pavlovich-Danis, ARNP-C, MSN Describe the diagnostic process for vWD. Identify treatments and the educational needs of patients with vWD. Could these three very different patients have something in common? Are their symptoms being evaluated or treated when a true underlying problem remains unnoticed? von What? Erik von Willebrand, MD, first described vWD in 1925 after studying a family of women from Aland Islands, Finland, who had extreme menstrual bleeding. One member was a 12-year-old girl who died during her first menstrual period. vWD occurs in 1% to 2% of the US population. Unlike hemophilia, it occurs equally among genders, yet women are affected more severely because of menstruation and childbirth. Research has shown that white women (15.9%) are more likely than black women (1.4%) to have vWD. Many with the disorder are unaware of the true cause of their symptoms or that treatment is available. While there is no cure, it can be treated. Without proper diagnosis, people with vWD can die unnecessarily during surgery, trauma, or menses. Hemostasis and the vW Factor Normal blood clotting requires a series of reactions among blood factors, proteins, and platelets to form the platelet plug that ultimately creates a fibrin clot that, in turn, stops blood from leaking from vessels. In vWD, an interruption in the normal clotting process causes bleeding into the skin and from mucous membranes, especially the nose, mouth, gums, gastrointestinal/genitourinary tract linings, and the uterus. von Willebrand factor (vWF) is a glue-like, high-molecular-weight protein necessary for platelet adhesion and formation of the platelet plug. Produced by cells lining vessel walls, it is also a carrier protein for plasma factor VIII (classic hemophilia A factor).

37. EMedicine - Von Willebrand Disease : Article By John D Geil, MD von willebrand Disease Although referred to as a single disease, von willebranddisease (vWD) is in fact a family of bleeding disorders caused by an http://www.emedicine.com/ped/topic2419.htm

(advertisement) Home Specialties CME PDA ... Patient Education Articles Images CME Patient Education Advanced Search Link to this site Back to: eMedicine Specialties Pediatrics Hematology Von Willebrand Disease Last Updated: May 24, 2002 Rate this Article Email to a Colleague Synonyms and related keywords: vWD AUTHOR INFORMATION Section 1 of 10 Author Information Introduction Clinical Differentials ... Bibliography Author: John D Geil, MD , Associate Professor, Department of Pediatrics, University of Kentucky Children's Hospital John D Geil, MD, is a member of the following medical societies: American Academy of Pediatrics , and American Society of Pediatric Hematology/Oncology Editor(s): J Martin Johnston, MD , Consulting Staff, Department of Pediatrics, Division of Hematology-Oncology, Saint Luke's Mountain States Tumor Institute; Robert Konop, PharmD , Clinical Assistant Professor, Department of Pharmacy, Section of Clinical Pharmacology, University of Minnesota; James L Harper, MD , Director of Nebraska Regional Hemophilia Treatment Center, Associate Professor, Department of Pediatrics, University of Nebraska Medical Center;

38. AHF - Von Willebrand Disease In Women von willebrand DISEASE IN WOMEN. An Introduction to the Basics. von willebrandDISEASE IN WOMEN INTRODUCTION TO THE BASICS - 1 CEU. EVALUATION. http://www.ahfinfo.com/ahfinfo/vonWillebrandinwomen.html

AHF, Inc. E-MAIL: info@ahfinfo.com AHF® Inc. Privacy Policy VON WILLEBRAND DISEASE IN WOMEN An Introduction to the Basics vWd in Women Von Willebrand disease (vWd) is characterized by the inability of the blood to clot normally. Blood is a fluid carried through the body in tubes called arteries, veins, and capillaries. When a tube is injured, a small hole forms, letting blood flow out. Stopping the flow of blood, or clotting, is necessary. Blood clotting is a process that requires the following three steps to be successful. Vasoconstriction - the blood vessel narrows and slows the passage of blood from the hole Clot - clotting factors and proteins in the blood, stop at the site, form a solid fibrin clot, and seal the hole, stopping the flow blood If any of these steps is missed or does not work correctly, no clot is formed. The missing, defective, or poorly working element in vWd is a protein called vWf. VWf is a substance made by the lining cells of the blood vessels. VWf acts as a "catcher’s mitt" to bind platelets to the internal site of the "hole in the vessel" creating a plug. A person with vWd may experience the inability to form a platelet plug from several kinds of events. Such events may include bleeding from injury, surgery, or from a spontaneous bleed. VWf also carries and protects Factor VIII (FVIII). Lack of FVIII will additionally cause a disruption in the entire clotting chain (cascade) making clot formation slow or unlikely. Without medical treatment to promote and sustain clotting, internal bleeding may continue and may cause long-term damage.

39. AHF - Von Willebrand Disease Disclaimer Privacy Policy. von willebrand DISEASE IN WOMEN An Introduction tothe Basics 1 CEU credit through the Case Managers Society of America (CMSA). http://www.ahfinfo.com/ahfinfo/vonwillebrandintro.html

AHF, Inc. E-MAIL: info@ahfinfo.com AHF® Inc. Privacy Policy VON WILLEBRAND DISEASE IN WOMEN An Introduction to the Basics 1 CEU credit through the Case Managers Society of America (CMSA) PRESENTATION AND DISCUSSION INCLUDE: What characterizes von Willebrand disease in women? What is the inheritance of von Willebrand disease? What are some common symptoms of von Willebrand disease in women? Are there diagnostic tests for von Willebrand disease? What are the common misdiagnoses and possible results of misdiagnosis? Are there treatments for women with von Willebrand disease? This is the outline for one of the six CEU presentations available through AHF. Please contact us if you are interested in arranging a presentation for your Center or organization at 800-243-4621 or E-mail.

40. WYETH: Hemophilia Information At Hemophiliavillage.com Brought To You By Wyeth G Also includes information on von willebrand disease. von willebranddisease. Also includes information on von willebrand disease. http://www.hemophilia-village.net/von-willebrand-disease.htm

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