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         Akinetic Mutism:     more detail
  1. Preserved auditory cognitive ERPs in severe akinetic mutism: a case report [An article from: Cognitive Brain Research] by L. Naccache, M. Obadia, et all 2004-04-01

1. Akinetic Mutism - Medical Dictionary Of Popular Medical Terms To Help You Better
An article about akinetic mutism, what it is, the cause and symptoms.Category Health Conditions and Diseases akinetic mutism...... akinetic mutism A state in which a person is unspeaking (mute) andunmoving (akinetic). A textbook on clinical neurology observes
http://www.medterms.com/script/main/art.asp?articlekey=6990

2. Meaning Of Akinetic Mutism
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Dictionary

Pathol., Psychiatry.
a state of apparent alertness with normal eye movements but no speech or other voluntary motion, usually due to a stroke.
akinete
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3. Meaning Of Akinetic Mutism
Dictionary entry for akinetic mutism
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Dictionary

Pathol., Psychiatry.
a state of apparent alertness with normal eye movements but no speech or other voluntary motion, usually due to a stroke.
akinete
Akins

4. Arousal And Gating In Neurology Of Impaired Consciousness
Partial loss of such grating processes would attend hyperkinetic mutism, akinetic mutism, or temporal lobe seizures.
http://www-users.med.cornell.edu/~jdvicto/scpl00.html
The Role of Arousal and "Gating" Systems in the Neurology of Impaired Consciousness
Nicholas D. Schiff and Fred Plum
Journal of Clinical Neurophysiology 17, 438-452 (2000)
Abstract
Related publication: emphasis on neurobiology
Related publication: emphasis on therapeutic strategies

Publications related to consciousness and brain dynamics

Return to publications list

5. Member Sign In
A 76year-old man developed akinetic mutism after 3 days of receivinglow-dosage baclofen. Focus On
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6. WorldMedicus
A description of akinetic mutism, with synonyms, related subjects and a link to reviews and editorials.
http://www.worldmedicus.com/servlet/Controller/$7006041601950000.sj/

7. ELibrary.com - The Mosby Medical Encyclopedia 10-01-1996, 'akinetic
eLibrary is the subscription based online library for fun or research. Find out more about securing your guaranteed Free 7day trial with your credit card and retrieve 'eLibrary.com - The Mosby Medical Encyclopedia 10-01-1996, 'akinetic mutism''
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8. DIRECTORY.TERADEX.COM - Health/Fitness/Diseases/Neurological Disorders/Brain Dis
Medicine Net An article about akinetic mutism, what it is, the cause and symptoms.
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9. Akinetic Mutism - General Practice Notebook
medical information from General Practice Notebook. akinetic mutism.akinetic mutism is a variety of stupor in which the patient is
http://www.gpnotebook.co.uk/cache/483393567.htm
akinetic mutism Akinetic mutism is a variety of stupor in which the patient is unable to talk or carry out purposeful behaviour but may lie with eyes open, seemingly unaware of what is going on around him. It results from bilateral damage to the orbital surface of the frontal lobes. The patient appears awake and has normal ocular movement but does not speak, is incontinent, and has minimal motor response to painful stimulation. It is seen in severe anterior cerebral artery strokes and less frequently, in hydrocephalus.
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10. A Case Of Unpaired Anterior Cerebral Artery Occlusion Producing Akinetic Mutism
Volume 47 Issue 2 1999 LETTERS TO EDITOR VOL472 A Case of Unpaired Anterior Cerebral Artery Occlusion Producing akinetic mutism A. Oommen, M. Madhusudanan Department of Medicine, Medical College Kottayam, Kerala, India. ACA occlusion by an embolus from the heart after a silent myocardial infarction producing akinetic mutism is presented.
http://www.neurologyindia.com/vol47-2/1136fl.shtml
Neurology India Volume 47 Issue 2 1999 LETTERS TO EDITOR VOL47-2 A Case of Unpaired Anterior Cerebral Artery Occlusion Producing Akinetic Mutism
A. Oommen, M. Madhusudanan
Department of Medicine, Medical College Kottayam, Kerala, India.
Aplasia or congenital absence of one anterior cerebral artery (ACA) is seen in only 1% of angiograms. ACA territory infarcts constitute only 0.6% to 3% of all acute ischaemic strokes. Bilateral infarcts due to unpaired ACA occlusion is still more rare. A case of unpaired ACA occlusion by an embolus from the heart after a silent myocardial infarction producing akinetic mutism is presented.
A 49 year old former airman was admitted with history of sudden onset of loss of consciousness and right focal seizures becoming generalized. He had exertional breathlessness for two days prior to admission. He was a heavy smoker and alcoholic. On admission, he was unconscious but his vital signs were stable. Ocular fundi were normal. He was moving all the four limbs equally. Plantars were equivocal. There was a loud fourth heart sound but no cardiac enlargement or murmurs. Seizures were controlled with intravenous phenytoin and diazepam. The next day, the patient was noticed to be more alert. He was opening his eyes, had spontaneous blinking and was following the examiner with his eyes. He was however mute and incontinent. All deep tendon jerks were brisk. Gegenhalten and grasp reflex were present bilaterally. Sensations could not be tested.

11. University Of Miami School Of Medicine - Glossary - Akinetic Mutism
Medical Dictionary. akinetic mutism. akinetic mutism A state in whicha person is unspeaking (mute) and unmoving (akinetic). A textbook
http://www.med.miami.edu/patients/glossary/art.asp?articlekey=6990

12. Assc-seminar-impaired.txt
and coma, vegetative states, akinetic mutism, absence and partial complex seizures, hyperkinetic mutism, and others.
http://tvisnius.ucs.indiana.edu/tom/assc/assc-seminar-impaired.txt

13. Ask Jeeves: Search Results For "Akinetic Mutism"
All Web Sites for akinetic mutism . Search Results 1 10, Next . powered by SMARTpages.com.Ask Jeeves a question about akinetic mutism Search the Web for
http://webster.directhit.com/webster/search.aspx?qry=Akinetic Mutism

14. Ask Jeeves: Search Results For "Akinetic"
She has been in a comalike state known as akinetic mutism for ten yearsand receives around the clock care from a staff of nurses
http://webster.directhit.com/webster/search.aspx?qry=Akinetic

15. Coma And Other Disorders Of Consciousness - Introduction
Cairns, H., RC Oldfield, JB Pennybacker And D. Whitteridge akinetic mutismwith an epidermoid cyst of the 3rd ventricle Brain 64 (1941) 273290.
http://sommeil.univ-lyon1.fr/articles/jouvet/hcn_69/contents.html
Coma and other disorders of consciousness Jouvet M.
Handbook of Clinical Neurology Vol.3. P. J. Vinken and G. W. Bruyn , eds. North-Holland Publishing Company. Amsterdam,(1969) TABLE OF CONTENTS Introduction Physiopathological basis of coma (introductory remarks) Nervous structures necessary for consciousness Periodic physiological dissolution of consciousness: sleep and coma ... Tentative anatomoclinical classification FIGURES Select a figure Figure 1 Figure 2 Figure 3 Figure 4 Figure 5 Figure 6 Figure 7 Figure 8 Figure 9
PRINT Printable version
MICHEL JOUVET Page of Michel Jouvet His articles on this server
Introduction
and of reactivity , will lead to another definition borrowed from psychophysiology. According to this definition, consciousness is that central nervous process which gives significance to a stimulus from the external environment. We can thus understand by consciousness that function of the nervous system which is concerned with the perceptual experience of information from the environment and from our own body (Alajouanine 1957). The multiple disintegration of consciousness observed in coma can therefore be defined as the absence, in the patient, of objective clinical (or paraclinical) signs of appreciation of his environment. It is this behavioural deficiency that the clinician explores by simple means: failure to rouse a comatose patient by calling his name or applying a painful stimulus.

16. Tentative Anatomoclinical Classification
(1941) under the name of akinetic mutism. 16 (1964) 285289. Daly, DD And JG.Loveakinetic mutism (a case report) Neurology (Minneap.) 8 (1958) 238-260.
http://sommeil.univ-lyon1.fr/articles/jouvet/hcn_69/p8.html
Coma and other disorders of consciousness Jouvet M.
Handbook of Clinical Neurology Vol.3. P. J. Vinken and G. W. Bruyn , eds. North-Holland Publishing Company. Amsterdam,(1969) TABLE OF CONTENTS Introduction Physiopathological basis of coma (introductory remarks) Nervous structures necessary for consciousness Periodic physiological dissolution of consciousness: sleep and coma ... Tentative anatomoclinical classification FIGURES Select a figure Figure 1 Figure 2 Figure 3 Figure 4 Figure 5 Figure 6 Figure 7 Figure 8 Figure 9
PRINT Printable version
MICHEL JOUVET Page of Michel Jouvet His articles on this server
Tentative anatomoclinical classification
By correlating the preceding classification with anatomical observations on our own cases and others described in the literature, we have been able to distinguish four main anatomoclinical stages in prolonged coma ( Fig.8 The reactive apathic hypoperceptive syndrome The reactive hyperpathic-hypertonic aperceptivity syndrome In all the cases, the lesion is similar. There is either massive cortical involvement (Denst et al. 1958) or diffuse degenerative changes in the white matter of the cerebral hemispheres. The brainstem is intact in the majority of cases (with the exception of the pyramidal fibres which frequently show signs of degeneration). The areactive apathic normotonic aperceptivity syndrome This group concerns cases of very deep coma in which survival is usually limited to a few weeks. Perceptivity is lost (P5). Nonspecific reactions are altered (R2-R3) as well as reaction to pain (D2-D3), but autonomic reactions are normal. In most cases, there is no definite hypertonicity. Patients described by Jefferson (1952) under the name of parasomnia, by French (1952) under the name of prolonged uncounsciousness, and by Cravioto et al. (1958), and Trillet (1961), present the same symptomatology. The lesion common to all these patients is one affecting the upper part of the brainstem (mesencephalic reticular formation), but in most cases, there were also associated lesions of the cortex or white matter. It appears that total or subtotal destruction of the reticular system is responsible for the more severe losses of reactivity.

17. Vol.8 - 3. Establishment Of The CJD Surveillance Unit
4.4/1.11.3; S50 Allen paras 13-14 3 Myoclonus - muscle spasms 4 akinetic mutism- impairment of voluntary muscle movement, including the loss of speech 5 EEG
http://www.bseinquiry.gov.uk/report/volume8/chapterc.htm
Quick navigation menu Home The Inquiry Report Download report as PDF Evidence Contact details Order a copy Help Search Volume Specific - Index List of Acronyms Who's Who Volume 8: Variant CJD
3. Establishment of the CJD Surveillance Unit
Review of the CJDSU by the Allen Committee

4 April 1991

1 July 1991

22 February 1993

19 July 1995

The work of the CJDSU was reviewed by the MRC Allen Committee, chaired by Professor Ingrid Allen, which met four times between 1991 and 1995. This Committee was established on the basis of concerns raised by Professor Allen at a meeting of the MRC Coordinating Committee for Research on Spongiform Encephalopathies in Man (The Murray Committee; see vol. 2: Science ) in October 1990. She considered that the design of Dr Will's study could mean that atypical features of dementia, like those exhibited by patients developing CJD as a result of treatment with human growth hormone, might fall outside the study. A Clinical Subcommittee was therefore established to coordinate and facilitate studies relating to the epidemiological monitoring and neuropathological definition of human SEs, to monitor patients at risk of iatrogenic infection and to apply new methodologies and technologies to refine the definition and improve diagnosis of SEs. The Allen Committee had powers to co-opt relevant experts when necessary. Dr Will was a co-opted member of the group.

18. Vol.8 - 6. Diagnosis, Treatment And Care Of VCJD Patients
Next Return to top of page 1 IBD3 tab 9 2 Dysaesthesiae unpleasant abnormalsensations 3 akinetic mutism - paralysis and inability to speak 4 IBD3 tab 9.
http://www.bseinquiry.gov.uk/report/volume8/chaptee2.htm
Quick navigation menu Home The Inquiry Report Download report as PDF Evidence Contact details Order a copy Help Search Volume Specific - Index List of Acronyms Who's Who Volume 8: Variant CJD
6. Diagnosis, treatment and care of vCJD patients
Symptoms of vCJD
On 21 March 1996, the CJDSU circulated to all neurologists in the UK a description of the clinical and pathological features of the new phenotype. The clinical features of the new phenotype of CJD described in the circular were as follows:
  • An early age of onset or death (average 27.6 years, range 18-41 years).
  • A prolonged duration of illness (average 13.1 months, range 7.5-24 months).
  • A predominantly psychiatric presentation including anxiety, depression, withdrawal and progressive behavioural changes.
    • The first evidence of neurological involvement in four patients was dysaesthesiae in the limbs and/or face.
    • Development of a cerebellar syndrome with problems with gait and limb muscle coordination after a period of weeks or months.
    • Development of forgetfulness and memory disturbance, often late in the clinical course, which progressed to severe cognitive impairment and a state of akinetic mutism
  • 19. 02-13
    and empirically based taxonomy for these primary disorders of consciousness, involvingcoma, persistent vegetative state, akinetic mutism, hyperkinetic mutism
    http://www.imprint-academic.demon.co.uk/T2000/02-13.html
    Emotion
    Peri-Reticular Substrates of Emotion: The ‘Centrecephalon’ and Consciousness
    With the exception of work by Panksepp, Newman and Baars, and Damasio, there has been virtually no systematic work in consciousness theory on systems beneath the thalamus in terms of their critical participation in foundations for consciousness, although virtually everyone agrees that numerous reticular systems, particularly the core monoamine nuclei, are essential for consciousness. However, beyond notions of the ‘non-specific arousal’ functions supported in these core nuclei, the ventral brain gets very little attention and consciousness theory outside of the above noted authors.
    This talk will outline the columnar architecture and connectivities of PAG, its role in the organizing prototypes states of emotion, and the re-entry of PAG with the extended reticular thalamic activating system (ERTAS). At the end we will outline some potential implications of these connectivities for possible functional correlates of PAG networks that are just starting to be mapped. Over all, we will look at many lines of evidence that PAG should be conceptualized as a peri-reticular structure that has a foundational role in emotion, and in generating the meaningful organization of behavior by the brain through prototype emotional states. Cerebral Organization of Self, Two Types of Emotions and Consciousness

    20. Searchalot Directory For Akinetic Mutism
    Related Web Sites. Medicine Net An article about akinetic mutism,what it is, the cause and symptoms. WorldMedicus - A description
    http://www.searchalot.com/Top/Health/ConditionsandDiseases/NeurologicalDisorders
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    • WorldMedicus - A description of akinetic mutism, with synonyms, related subjects and a link to reviews and editorials.
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