Product Description
Research into the biochemical basis of toxicology has expanded rapidly over recent years, amidst concerns over the adverse effects of drugs, environmental pollution and occupational hazards.
Following on from the acclaimed first two editions of Principles of Biochemical Toxicology, John Timbrell has expanded the text to include:

Customer Reviews (1)

Biochemical Toxicoly
This book is a powerfull tool and can be used not only in Biochemistry but in many others fields like Applied Physics. That's the best. Congratulations. ... Read more

Product Description
Environmental Toxicology is a comprehensive introductory textbook dealing with most aspects of the subject, from the molecular to the ecosystem level. Early chapters deal with basic to advanced concepts, methods and approaches. The next discusses the environmental toxicology of individual or groups of substances. The third part addresses complex issues, in which many of the concepts, approaches and substances covered in earlier parts are incorporated. The fourth part includes chapters on risk assessment, rehabilitation and regulatory toxicology. The book concludes with a summary of present and future areas of emphasis. Each chapter contains a comprehensive list of references and further reading, case studies from different jurisdictions, and student exercises. ... Read more

Customer Reviews (2)

Recently Purchased Book
Just bought an Environmental Toxicology book online.I got the book when it was said to arrive and was in the condition stated when I purchased the book.Overall, I couldn't be any happier!

Highly recommend
This book was recommended to me by an expert in the field, and I consider it to be a very fine resource. ... Read more

Product Description
Analytical toxicologists are involved in the analysis of drugs and poisons in biological samples in different environments: therapeutic drug monitoring, drugs in sport, postmortem examinations, etc. Following the developments of LC-MS in the last decade and its establishment as the method of choice in the pharmaceutical industry (analytical R&D), the technique has gained favour in other scientific disciplines including analytical toxicology. This is notably due to the fact that purchase and operative costs of the equipment have gradually decreased over the same period. Many scientists in the field of analytical toxicology have already adopted LC-MS in their daily work, and this is illustrated by the increasing numbers of research papers published and presented at relevant conferences (The International Association of Forensic Toxicologists, Society of Forensic Toxicologists). ... Read more

Customer Reviews (1)

Review of liquid chromatography-mass spectrometry (LC-MS) applications in toxicology
Applications of LC-MS in Toxicology is presented by Dr. Aldo Polettini and seventeen other authors. This timely monograph features a unique combination of advances in technology with practical challenges from experienced users. In addition to sufficient background information, topics ranging from current practices to associated applications are covered with reference to specific examples. The introductory and application chapters provide comparable summaries of the existing instrumentation; a format which allows the reader to choose a topic of interest. In return, they will obtain a synopsis of the basic principles pertaining to the selected subject. Additionally, descriptions of commonly used ionization and mass analysis techniques are given together with appropriate considerations and examples. There are twelve chapters with close to 900 references, which cover details ranging from theoretical concepts to operational implications regarding the use of conventional LC-MS instrumentation. The book is presented for researchers and practitioners but also provides an appropriate introduction for novice scientists. ... Read more

Product Description
Written by international authorities in ocular toxicology, including the Founder of The National Registry of Drug-Induced Side Effects and its current Director, this essential resource provides the clinically relevant information you need to effectively diagnose and manage herbal, chemical, and drug-related ocular problems. Comprehensive coverage of all drugs' generic and trade drug names, primary uses, ocular and systemic side effects, and clinical significance make this book - like its best-selling predecessor, Drug-Induced Ocular Side Effects - the ideal reference for quick, on-the-spot consultation.

• Leaders in the field provide need-to-know information on all aspects of ocular toxicology-all in one concise reference.
  
• Data from the National Registry of Drug Induced Ocular Side-Effects (Casey Eye Institute, Portland, OR) and the World Health Organization (Uppsala, Sweden) help you recognize and avoid drug-induced ocular side effects.
  
• A highly templated format makes retrieval of essential knowledge quick and easy.
  
• A wealth of full-color photographs provide vivid, visual diagnostic guidance.
  
• The latest information on approved medications helps you stay up to date and provide state-of-the-art care.
  
• Extensive coverage of principles of therapy, ocular drug delivery, methods to evaluate drug-induced visual side effects, and the role of electrophysiology and psychophysics gives you the knowledge you need to manage any challenge in ocular toxicology
  
• Authoritative guidance on ocular drugs and their use in pregnancy helps you safely manage the unique needs of these patients.
  
• The inclusion of the WHO classification system helps you determine whether a particular side effect is certain, probable, or likely to occur.

Product Description
In April 2000 researchers from around the world met in Lexington, Kentucky to bring together the very latest information on the chemistry and biological effects of the environmental pollutants known as Polychlorinated Biphenyls (PCBs). The result is a comprehensive and extensive treatment of the very latest findings on all significant subjects relating to PCBs and their health risks. The thorough introduction and sixty-two scientific papers presented here represent the most up-to-date research by scientists in government, private industry, and academia. ... Read more

Product Description
This textbook is based on Volume 1 of "Clarke's Analysis of Drugs and Poisons" by Moffatt, Osselton and Widdop (ISBN 9780853694731). The text is aimed at students undertaking Forensic Science degrees (B.Sc or M.Sc). Existing chapters from Clarke's have been edited for a student audience.Forensic science courses in the UK have been developed since 1990. To date, there are over 50 degree programmes (now also including M.Sc) and over 350 possible course combinations with a Forensic element to them. A brief survey of student intake for these courses over the past three years revealed an exponential rise in numbers which is set to continue. This situation is mirrored in the US, Europe and the rest of the world.Analytical Toxicology is an important subject within Forensic Science and this textbook has been developed based on Volume 1 of "Clarke's Analysis of Drugs and Poisons" (ISBN 9780853697114). The existing chapters from Clarke's have been edited for a student audience, rendering the material suitable for a recommended course textbook.The editors, Sue Jickells and Adam Negrusz are actively engaged in teaching analytical toxicology at respected universities (King's College, London and University of Illinois at Chicago).This title will be of interest to academics teaching Forensic Science, Analytical Chemistry, Biomedical Science and to students of Forensic Science (MSc and BSc). ... Read more

Customer Reviews (2)

Exxcellent text
Very thorough text.Fundamental and with appplications. Although not immediately applicable in my lab, I appreciate having had for the first time a clear explanation of what Raman rays are and how their analysis is helped by Fourier transformation.

Still use it...
I had to buy this book for my Drug Chemistry and Toxicology class, however, I still reference it now.

This book provides a lot of necessary information in a very concise way. ... Read more

Product Description
Univ. of London, U.K. Review questions for the student preparing for an exam. Softcover. Trim size: 9.25 x 6 inches. ... Read more

Product Description

Reviews of Environmental Contamination and Toxicology attempts to provide concise, critical reviews of timely advances, philosophy and significant areas of accomplished or needed endeavor in the total field of xenobiotics, in any segment of the environment, as well as toxicological implications.

Product Description
A clear, straightforward resource to guide you through preclinical drug development

Following this book's step-by-step guidance, you can successfully initiate and complete critical phases of preclinical drug development. The book serves as a basic,comprehensive reference to prioritizing and optimizing leads, toxicity, pharmacogenomics, modeling, and regulations. This single definitive, easy-to-use resource discusses all the issues that need consideration and provides detailed instructions for current methods and techniques.

Each chapter was written by one or more leading experts in the field. These authors, representing the many disciplines involved in preclinical toxicology screening and testing, give you the tools needed to apply an effective multidisciplinary approach. The editor, with more than thirty years' experience working with pharmaceutical and biotechnology companies, carefully reviewed all the chapters to ensure that each one is thorough, accurate, and clear.

Among the key topics covered are:
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In vitro mammalian cytogenetics tests
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Phototoxicity
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Carcinogenicity studies
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The pharmacogenomics of personalized medicine
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Bridging studies
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Toxicogenomics and toxicoproteomics

Each chapter offers a full exploration of problems that may be encountered and their solutions. The authors also set forth the limitations of various methods and techniques used in determining the safety and efficacy of a drug during the preclinical stage.

This is a hands-on guide for pharmaceutical scientists involved in preclinical testing,enabling them to perform and document preclinical safety tests to meet all FDA requirements before clinical trials may begin. ... Read more

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Customer Reviews (1)

Outstanding tribute to the original Ellenhorn
The original Medical Toxicology by Matthew Ellenhorn was a fabulous resource for the clinical/medical toxicologist.That it is still widely used despite being published in 1988 is a testament to it's impact and utility.This third edition of Medical Toxicology goes back to those first edition roots:a plethora of useful topics written in a clear, consice manner.

The book provides excellent detail needed for the understanding of a wide range of toxicologic problems.Treatment recommendations are as evidence-based as possible given the field of study.

The third section of the book focuses on one of the key elements of being a toxicologist:detective!The section is titled, "Diagnosis of the Poisoned Patient: The Toxicolgist as Sleuth".Rarely do patients present with a (accurate) diagnosis.It's the job of the clinician to take all the available information, work through the possibilities, and identify the most likely agents that could be causing the observed effects.

This is an outstanding resource and should be considered for critical care and emergency clinicians as well as poison center staff (especially those still in training in these areas).Given the popularity of TV and movie scripts that include toxicologic information (e.g., CSI, ER, etc.) those writers would do well to review this text. ... Read more

Product Description
In the unique vignette format of the Pearls Series, this book presents a variety of problems that challenge emergency physicians and toxicologists in everyday practice. For each patient, the author presents the case scenario, physical findings, lab data, and a clinical photo, and the reader is challenged to formulate a diagnosis and a treatment strategy. The next page reveals the diagnosis, discusses the condition, and leaves the reader with several "pearls of wisdom" distilled from the case. ... Read more

Product Description
This new book, written by two outstanding scientists in the field, describes the basic principles of toxic mechanisms and organ toxicity, providing detailed information on specific mechanisms or chemicals for exemplification. The goal is to provide sufficient information that the reader becomes familiar with the basic concepts in toxicology to enable him or her to understand the basic principles in toxicology and to evaluate the risks at given exposures. With this basic understanding the reader also will be able to critically evaluate the available information on a chemical and to identify data gaps.

In addition to the introductory chapters the book will offer the following systematic information, presented in six special sections:

• Principles in Toxicology
• Organ Toxicology
• Methods in Toxicology
• Risk Assessment
• Risk Management
• Toxicity of Chemicals

Fulfilling a demand for such a book, this will be a welcomed introductory text for students and non-experts alike to focus on and understand the principles of hazard identification and risk assessment of toxicants. Relevant to all those studying toxicology, biochemistry, biology, medicine and chemistry, as well as toxicologists in hospitals, universities and in industry. ... Read more

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A review of the effects of toxicants on the male and female reproductive systems and discussion of current tests to assess reproductive toxicity. This text reviews normal reproductive function, explains the mechanisms by which toxicants disrupt ... Read more

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An essential resource for graduate students, academic and industrial toxicologists, and environmental health scientists and professionals

Over the course of thirty years and three editions, Introduction to Biochemical Toxicology has been an important source for coverage of the ongoing quest to define the biochemical, cellular, and molecular events induced by toxicants at the cellular and organismic levels. Now, as the principles and methods of molecular and cellular biology as well as genomic sciences play an ever increasing role in mechanistic toxicology, significant changes have been made to the book, resulting in this important new edition-now titled Molecular and Biochemical Toxicology, Fourth Edition.

Much more than an introductory text, this crucial new edition has been completely revised to provide timely and thorough coverage of the underlying biochemical, molecular, and cellular mechanisms through which toxicants produce their adverse effects. Toxicological issues are covered from the molecule to the cell to the organ level. Complex methods used in toxicology are also described in a straightforward, easy-to-understand style. Additional features of this new edition include:

• New chapters that explore the interface between toxicology and genomic sciences, including: bioinformatics, proteomics, metabolomics, and toxicogenomics
• Increased emphasis on structure, mechanism, and regulation of xenobiotic metabolizing enzymes, toxicogenetics, and xenobiotic transporters
• Additional new chapters on: molecular epidemiology and genetic susceptibility, DNA damage and mutagenesis, DNA repair, mechanisms of cell death, mitochondrial dysfunction, metals, reproductive toxicology, developmental toxicology, and reactive oxygen/metabolites and toxicity

Molecular and Biochemical Toxicology, Fourth Edition guides graduate students, toxicologists, and environmental health professionals through the principles of molecular and biochemical toxicology and the complex mechanisms of toxicity. Whether it's used in the classroom or in industry, research, or academia, this book is essential for anyone interested in understanding the molecular mechanisms through which toxicants produce adverse effects. ... Read more

Product Description
Reflecting more than a decade’s worth of changes, Animal Models in Toxicology, Second Edition is a practical guide to the common statistical problems encountered in toxicology and the methodologies that are available to solve them. The book presents a historical review of the use of animal models and an overview of broad considerations of metabolism and relevance used in toxicology. Individual chapters covering the eight major species used in toxicology and experimental biology form the core of the book. With contributions from experts in toxicology, toxicological pathology, and species-specific metabolism, each of these chapters provide an excellent introductory “course” along with guidance to the literature for more detailed understanding.

The book goes on to make the case for a range of species not commonly used for safety assessment studies but which may provide useful alternative models for some specific endpoints. The chapter authors discuss special considerations regarding the evaluation and interpretation of the clinical pathology of the eight major model species as well as how to select a model species and how to extrapolate the results to humans. They detail potential pitfalls and situations that cause either human or model to be significantly more sensitive than the other or totally irrelevant to each other. The book concludes with an overview of the increasingly complex laws and regulations that govern how laboratory animals are obtained, maintained, and utilized, and an appendix that provides a quick guide to commercial sources of laboratory animals. ... Read more

Customer Reviews (1)

Informative but redundant
Though I have yet to read the book in its entirety, I have skimmed through several chapters & I find that much of the techniques appear to be written in redundancy.Perhaps I have high expectations, but perhaps techniques that are performed in the same manner between species could be consolidated and referenced.The information for actual toxicology in the various species is very useful. ... Read more

Product Description
A fully updated and expanded edition of the bestselling guide on toxicology and its practical application

The field of toxicology has grown enormously since Industrial Toxicology: Safety and Health Applications in the Workplace was first published in 1985. And while the original edition was hugely popular among occupational health professionals, the time is ripe to address toxic agents not only in the industrial setting but also in the environment at large. Renamed Principles of Toxicology: Environmental and Industrial Applications, this new edition provides health protection professionals as well as environmental scientists with precise, up-to-date, practical information on how to apply the science of toxicology in both the occupational and environmental setting. Through contributions from leading experts in diverse fields, Principles of Toxicology, Second Edition features:
* Clear explanations of the fundamentals necessary for an understanding of the effects of chemical hazards on human health and ecosystems
* Coverage of occupational medicine and epidemiological issues
* The manifestation of toxic agents such as metals, pesticides, organic solvents, and natural toxins
* Special emphasis on the evaluation and control of toxic hazards
* Specific case histories on applying risk assessment methods in the modern workplace
* Ample figures, references, and a comprehensive glossary of toxicological terms ... Read more

Customer Reviews (1)

Lots of Useful Information
I bought this for my master's degree in industrial toxicology and almost all the topics covered at various points in the degree program are also covered in this book.Very useful tool for a degree in toxicology. ... Read more

Product Description
"Leading experts in the fields of toxicology and emergency medicine have written this new textbook....it provides the practitioner with up-to-date resources to evaluate toxicology laboratory findings in the clinical setting….I highly recommend this book not only as a teaching reference for clinical toxicology, but as a book that should also be in the reference libraries of forensic toxicologists, emergency room physicians, and poison control centers."Clinical Chemistry, 48, 6, 2002

An outstanding group of experts in laboratory medicine, emergency medicine, and toxicology, from poison control centers and academic, governmental, and private laboratories has produced this unique textbook. The wide range of disciplines represented points to the very essence of the contemporary practice of toxicology: the dramatic advances in the care of the poisoned patient due to improved standards in the specialty of emergency medicine, the advent of regional poison centers over the past 25 years, and successful efforts of clinical toxicologists in adapting cost-effective technologies to support the changing diagnostic and treatment modalities used. Major topics include the epidemiology of poisoning and substance abuse; pharmacokinetic and toxicokinetic behavior of the most prevalent drugs of abuse, medications, and environmental poisons; clinical manifestations of poisons and approaches to diagnosis; critical appraisal of laboratory and point-of-care testing methods, sample types, and tests for sample adulteration; biological monitoring of chemical exposures; pharmacogenetic principles and toxicity risk assessment; principles and applications of advanced analytical techniques; and an assessment of the provision of clinical toxicology laboratory service that is based on examining clinical needs, technology requirements, and financial justifications. This textbook should be of interest to clinical pathologists; clinical chemists; laboratory directors, managers, supervisors, and technologists; medical toxicologists; pharmacists; poison control center specialists; and students, residents, and fellows. They will find in this book valuable and helpful information that will assist them in their practice and teaching of toxicology in the contemporary clinical laboratory environment. ... Read more

Customer Reviews (1)

CLINICAL TOXICOLOGY LAB REFERENCE
WHEN YOU ARE RASHING TO FIND A TOOL TO INVESTIGATE A CAUSE OF POISONING OF BELOVED KIDS YOU WON'T FIND BETTER THAN THIS REFERENCE ... Read more