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This book is a welcome overview of the involvement of mitochondria in cell death and disease, an extraordinarily active research area of major importance to both basic biology and medical science. Clear and thorough chapters present the current approaches leading research teams are taking to examine the role that mitochondria play in inducing the death of various cell types, including heart, brain, and liver cells.

The volume is comprehensive in that it examines apoptosis and necrosis from multiple levels and perspectives. As well as covering the genetic and biochemical basis of mitochondrial involvement in cell death, it details how mitochondrial dysfunction could result in various neurodegenerative, inflammatory, and ischemic diseases, and the aging process. Researchers and postgraduates throughout the biological and medical sciences--particularly those investigating the causes and potential treatments of cancers, septic shock, Parkinson's disease, and Alzheimer's disease--will benefit from this book. ... Read more

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This series provides an information library on the main aspects of physical science, with an emphasis on enquiry; answering the questions that children ask and addressing the topics that they are required to research at this level. Each book contains aspects of science which are linked to everyday examples that will be familiar to the reader to aid understanding, before moving on to more complex topics. There are answers to key questions about the main topics at this level. The books also include experiments to illustrate the topic under discussion and to develop understanding of scientific methodology. Scientific measurement is covered and the more unusal or amazing applications. ... Read more

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The Worldwide Destinations and Companion Book of Cases Set brings together two essential and complimentary reference works offering comprehensive and up to date information, in one value for money package.

Worldwide Destinations provides comprehensive coverage of worldwide tourism destinations, examining the basic principles underlying the geography of tourist demand, supply and transportation, together with a broad survey of world tourism generating and destination regions.

Worldwide Destinations Casebook features over 40 comprehensive case studies of international tourism destinations, with brand-new cases studies drawn from all regions of the world. The case studies featured include The Galapagos: balancing resource conservation and tourism development, London Docklands regeneration, Re-visioning tired destinations: Australia's gold coast and Tourism in New York.

. Essential information in one package with fully updated statistics, new material on hot topics such as climate change and economic capacity, as well as a wealth of international case studies
. Full color layout packed with pedagogic features to aid learning
. Companion website materials available ... Read more

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The study of tourism and indeed the tourism industry is changing constantly. Contemporary Tourism: an international approach presents a new and refreshing approach to the study of tourism, considering issues such as the changing world order, destination marketing, tourism ethics and pro-poor tourism. In particular, it highlights the ongoing threats from terrorism and health scares faced by the tourism industry today, and discusses the related security and risk management strategies, illustrating the potential implications for the patterns and flow of tourism in the future.

Divided into five sections, each chapter has a thorough learning structure including chapter objectives, examples, discussion points, self review questions, checklists and case studies. Cases will be both thematic and destination-based and always international. They will be used to emphasise the relationship between general principles and the practice of tourism looking at areas such as business and special interest tourism and the role of technology.The five sections will cover: Contemporary Tourism Systems; The Contemporary Tourist; The Contemporary Tourist Destination; Tourism Futures; Teaching and Studying Contemporary Tourism. The text will also provide an annotated, authoritative and thorough set of resources to guide the reader through the topic area including online resource sites for both students and lecturers.

* Well respected author team bring a new and refreshing approach to the study of tourism
* A combination of contemporary and comprehensive international coverage
* Provides substantial support for both students and teachers, both within the text itself, as well as through the design of web-based student and instructor resources ... Read more

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Customer Reviews (3)

A 'must' for any interested in open source who would understand its ongoing evolution and potential
Chris DiBona, Danese Cooper and Mark Stone edit Open Sources 2.0: The Continuing Evolution, a collection of essays from today's tech leaders exploring open source's impact on the software industry. Open source is network- enabled distributed collaboration that holds the potential of changing not only online business itself, but the nature of collaboration. Articles address the future of open source in essays that cover not just the developing technology but the participation of international communities. A 'must' for any interested in open source who would understand its ongoing evolution and potential.

How OSS is changing the world as we know it...
Open Source Software (OSS) has radically redefined the landscape of the software industry and the Information Technology field.As much a mindset as a methodology, there are many elements of OSS that draw some of the deepest thinkers of our field.You can find some of those essays in the book Open Sources 2.0 - The Continuing Evolution, edited by Chris DiBona, Danese Cooper, and Mark Stone.There's a little something here for everyone...

Contents:
Part 1 - Open Source - Competition and Evolution: The Mozilla Project - Past and Future; Open Source and Proprietary Software Development; A Tale of Two Standards; Open Source and Security; Dual Licensing; Open Source and the Commoditization of Software; Open Source and the Commodity Urge - Disruptive Models for a Disruptive Development Process; Under the Hood - Open Source and Open Standards Business Models in Context; Open Source and the Small Entrepreneur; Why Open Source Needs Copyright Policies; Libre Software in Europe; OSS in India; When China Dances with OSS; How Much Freedom Do You Want?
Part 2 - Beyond Open Source - Collaboration and Community: Making a New World; The Open Source Paradigm Shift; Extending Open Source Principles Beyond Software Development; Open Source Biology; Everything Is Known; The Early History of Nupedia and Wikipedia - A Memoir; Open Beyond Software; Patterns of Governance in Open Source; Communicating Many to Many
Part 3 - Appendixes: The Open Source Definition; Referenced Open Source Licenses; Columns from Slashdot; Index

As with all compilations from various writers and authors, it's not possible to have all the articles flow with the same voice and pace.And really, they shouldn't.You're looking to get a wide array of opinions and insights, not a blended mind dump from a single writer.Conversely, you'll find that some of the articles resonate with you, and others have you moving into scan mode to get to the next one.If you keep that in mind as you're working through the book, you'll get a lot more out of it.

For me, there were two areas that were enjoyable and valuable.The story of how Wikipedia went through growing pains and worked through rules and culture was interesting.Likewise, the story of Slashdot and how it got to what it is today is insightful.I still don't care for the site, but you can't argue it's effect in the technology world.The most thought-provoking essays for me revolved around the commoditization of software.Coupled with a different book I recently finished, I realize that certain software vendors are in a very precarious position, and they are following the same path that has led others to destruction as they attempt to hold on to what doesn't work any more.Those essays would have been worth the cost of the book alone to me...

If you're part of the OSS movement, or if you're trying to understand how it will affect your business, this is a good book to read and ponder...

Interestingread on different facets of open source movement
This collection of essays on the open source movement could be called a second edition to the book "Open Sources: Voices from the Revolution" that was published in 1999. That book spent much space trying to argue that the open source movement was legitimate and here to stay. That argument has long since been settled, so this book takes up the current and future trends of the open source movement. The essays can be read in any order, and depending on your expertise, some may not be of any real interest to you- for example the open source biology essay might not be valuable to someone interested in network security. However, all essays are written to be accessible to a wide audience in spite of that fact. For example, I have no background in biology whatsoever, but I still found the essay on open source biology an understandable and interesting read. I particularly enjoyed the essay on the open source paradigm shift by Tim O'Reilly. His premise is that free and open source developers are in much the same position today that IBM was in 1981 when it changed the rules of the computer industry, but failed to understand the consequences of the change. This allowed others, Microsoft in particular, to reap the benefits. O'Reilly concludes thatexisting proprietary software vendors are no better off, playing by the old rules while the new rules are reshaping the industry around them. Another favorite of mine was on the commoditization of software in which it is explained that this process has been driven by standards, in particular by the rise of communications-oriented systems such as the Internet, which depend on shared protocols, and define the interfaces and datatypes shared between cooperating components instead of those components' internals. There are also two fascinating essays on the open source movement in China and India, neither of which was really a factor when the first edition of this book was published six years ago. I would recommend this book to anyone interested in where technology might be headed in the future, not just those who are employed in the tech industry. I notice that nothing about the contents of the book is currently shown by Amazon, so I show the table of contents here for the purpose of completeness:
The list of essays are:
1. The Mozilla Project: Past and Future by Mitchell Baker
2. Open Source and Proprietary Software Development by Chris DiBona
3. A Tale of Two Standards by Jeremy Allison
4. Open Source and Security by Ben Laurie
5. Dual Licensing by Michael Olson
6. Open Source and the Commoditization of Software by Ian Murdock
7. Open Source and the Commodity Urge: Disruptive Models for a Disruptive Development Process by Matthew N. Asay
8. Under the Hood: Open Source and Open Standards Business Models in Context by Stephen R. Walli
9. Open Source and the Small Entrepreneur by Russ Nelson
10. Why Open Source Needs Copyright Politics by Wendy Seltzer
11. Libre Software in Europe by Jesus M. Gonzalez-BarahonaGregorio Robles
12. OSS in India by Alolita Sharma and Robert Adkins
13. When China Dances with OSS by Boon-Lock Yeo, Louisa Liu, and Sunil Saxena
14. How Much Freedom Do You Want? by Bruno Souza
15. Making a New World by Doc Searls
16. The Open Source Paradigm Shift by Tim O'Reilly
17. Extending Open Source Principles Beyond Software Development
by Pamela Jones
18. Open Source Biology by Andrew Hessel
19. Everything Is Known by Eugene Kim
20. The Early History of Nupedia and Wikipedia: A Memoir by Larry Sanger
21. Open Beyond Software by Sonali K. Shah
22. Patterns of Governance in Open Source by Steven Weber
23. Communicating Many to Many by Jeff Bates and Mark Stone
Appendixes :
A. The Open Source Definition
B. Referenced Open Source Licenses
C. Columns from Slashdot

... Read more

Customer Reviews (2)

Deconstructing Coop
Coop, what can be said about the non-traditional depiction of work that embodies the illustrative nature of Coops portfolio? The answer is that Coop has the traditional style of a tattoo artist pin up and the ranges of visionary styles that create imagery that have strong Freudian ID overtones.

Bottom-line Coop is a fantastic and unique artist with a depth of perception in the human psychosis.

Devil of a good time...
A vast majority of Coop's art featured in Devil's Advocate are, in actuality, posters the artist was commissioned to create for various rock shows and punk concerts, with the challenging task of grabbing the attention of casual passers-by and hopefully get them to attend whatever concert or event they're promoting.

In this task you'll discover that Coop's posters more than succeed in catching your eye, in fact, they demand you stop and look!

Such posters include aliens wrestling with curvy female astronauts, a sleek Creature from the Black Lagoon, babes with hot rods, tiki temptresses and Betty page-esque hotties flirting at you from the poster in luscious color.

From another artist, all of this could of come across as vulgar and cheap, but instead, it oozes raw sexuality and is just a heck of a lot of fun.Don't miss out. ... Read more

Customer Reviews (2)

Deconstructing Coop
Coop, what can be said about the non-traditional depiction of work that embodies the illustrative nature of Coops portfolio? The answer is that Coop has the traditional style of a tattoo artist pin up and the ranges of visionary styles that create imagery that have strong Freudian ID overtones.

Bottom-line Coop is a fantastic and unique artist with a depth of perception in the human psychosis.

Devil of a good time...
A vast majority of Coop's art featured in Devil's Advocate are, in actuality, posters the artist was commissioned to create for various rock shows and punk concerts, with the challenging task of grabbing the attention of casual passers-by and hopefully get them to attend whatever concert or event they're promoting.

In this task you'll discover that Coop's posters more than succeed in catching your eye, in fact, they demand you stop and look!

Such posters include aliens wrestling with curvy female astronauts, a sleek Creature from the Black Lagoon, babes with hot rods, tiki temptresses and Betty page-esque hotties flirting at you from the poster in luscious color.

From another artist, all of this could of come across as vulgar and cheap, but instead, it oozes raw sexuality and is just a heck of a lot of fun.Don't miss out. ... Read more

Product Description
Explore the amazing world of matter-from the earliest ideas about the four elements to the discoveries about the atom.

DK gives a new look to the series that forever changed the nonfiction genre and set the standard for highly informative visual guides. This volume, and those to follow in future seasons, forms part of an indispensable library for the whole family. Focusing on contemporary and historical developments in the study of matter, this book features clear, expertly written text, color and black-and-white photos, charts, graphics, and 3-D models -- all of which combine to make complex scientific concepts easy to understand. ... Read more

Customer Reviews (2)

Incredibly interesting, but contains factual errors
On a certain page of "Matter" a callout next to a picture of a glass lens states that "glass flows over time".This is a widely believed myth that is simply not true.The "evidence" for the liquid nature of glass comes from old church and cathedral windows that appear to be thicker at the bottom as the glass has flowed over the centuries.This is not the case.Here is why they are thicker at the bottom:

"In Mediaeval times panes of glass were often made by the Crown glass process.A lump of molten glass was rolled, blown, expanded, flattened and finally spun into a disc before being cut into panes.The sheets were thicker towards the edge of the disc and were usually installed with the heavier side at the bottom."

Examples of other pieces of ancient glassware (Roman, etc.) exhibit no signs of glass "flow".

There's nothing the matter with this book!
"Eyewitness Matter" tells everything about Matter. It has chapters on solid matter, liquid matter and gas matter, plus chapters on molecules in motion, crystals, hot matter and more! All of the chapters in the book have descriptive information on the topics in Matter. If you have gotten the other Eyewitness Science Series books, then make sure you have this one. ... Read more

Product Description
American Beauty is a 1999 American drama film, directed by Sam Mendes and written by Alan Ball. Kevin Spacey plays Lester Burnham, a middle-aged office worker who has a midlife crisis after becoming infatuated with his teenage daughter's best friend. The film co-stars Annette Bening and Thora Birch as Lester's wife and daughter respectively. Mena Suvari, Wes Bentley and Chris Cooper also feature. American Beauty marked acclaimed theater director Mendes' film directorial debut; it was also Ball's first produced film screenplay. The film was financed by DreamWorks, which bought Ball's spec script for a six-figure sum in 1998. Spacey was Mendes' first choice for the role of Lester Burnham, though DreamWorks had urged the director to consider better-known actors; similarly, the studio suggested several actors for the role of Carolyn?Lester's wife?until Mendes cast Bening without DreamWorks' knowledge. Principal photography took place between December 1998 and February 1999 on soundstages at the Warner Bros. backlot in Burbank, California and on location in Los Angeles. The film underwent several changes during editing that affected its tone and eliminated expository bookend scenes. ... Read more

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Chapters: Marlin Briscoe, Martay Jenkins, Chris Bober, Chris Cooper, Kenny Onatolu, Robert Gordon, Keith Eloi, Zac Herold, Zach Miller, Rod Kush, Brad Beckman, Phil Wise, Ryan Krause. Source: Wikipedia. Pages: 41. Not illustrated. Free updates online. Purchase includes a free trial membership in the publisher's book club where you can select from more than a million books without charge. Excerpt: Marlin Oliver Briscoe (born September 10, 1945 in Oakland, California) is a former American collegiate and Professional Football wide receiver/quarterback who played professionally for nine years. Before being drafted by the American Football League's Denver Broncos in the 1968 Common Draft, Briscoe played high school football at Omaha South High School and college football at the University of Nebraska at Omaha. Briscoe was 5-foot-10 and 177 pounds when the AFL's Broncos took him in the 14th-round of the 1968 draft. He was eighth on the Broncos' QB depth chart in training camp. On September 29, 1968, starter Steve Tensi suffered a broken collarbone, and backup Joe DiVito was spotty. Head coach Lou Saban summoned Briscoe from the sidelines in the fourth quarter against the Boston Patriots. Briscoe's first play was a 22-yard completion. On his second series he orchestrated an 80-yard touchdown drive. He completed a 21-yard pass and ran for 38 more himself, carrying it the last 12 yards for the score. When Marlin Briscoe broke the Denver huddle and surveyed the Cincinnati Bengals defense as he walked to the line of scrimmage Oct. 6, 1968, he became the first starting black quarterback in the modern era, extending the American Football League's propensity to use blacks at positions they were denied in the NFL. Briscoe threw 14 touchdown passes that year, still Denver's rookie record. He completed only 41.5 percent of his passes, but averaged a very good 7.1 yards per attempt and his 17.1 yards per completion led the American Football ...More: http://booksllc.net/?id=1922788 ... Read more

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Chapters: Yale Bulldogs Men's Basketball Coaches, Yale Bulldogs Men's Basketball Players, John Sherman Cooper, Chris Dudley, Tony Lavelli, Tim O'shea, Payne Whitney Gymnasium, Tom Brennan, Charles Phelps Taft Ii, Howard Hobson, Steve Pikiell, Elmer Ripley, Mike Laplante, Ken Loeffler, Earl G. Graves, Jr., Levi Jackson, James Jones, Daniel Okonkwo, Dick Kuchen. Source: Wikipedia. Pages: 61. Not illustrated. Free updates online. Purchase includes a free trial membership in the publisher's book club where you can select from more than a million books without charge. Excerpt: John Sherman Cooper (August 23, 1901 February 21, 1991) was a liberal Republican United States Senator from Kentucky who served a total of twenty years (1946-1949, 1952-1955, 1956-1973). He was a captain in the United States Army, and served as a member of the Warren Commission, and as U.S. ambassador to India and East Germany. John Sherman Cooper was born in Somerset, Pulaski County, Kentucky. After a year at Centre College in Danville, Kentucky, Cooper transferred to Yale, where he was captain of the basketball team, and a member of Skull ... Read more

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Chapters: George Ellis, Lionel Cooper, Chris Brink, Francis Guthrie, Peter Sarnak, Abraham Manie Adelstein, Percy Deift, Otto Brune, Nigel Weiss, Stanley Skewes. Source: Wikipedia. Pages: 37. Not illustrated. Free updates online. Purchase includes a free trial membership in the publisher's book club where you can select from more than a million books without charge. Excerpt: George Francis Rayner Ellis, FRS, (born August 11, 1939) is the Emeritus Distinguished Professor of Complex Systems in the Department of Mathematics and Applied Mathematics at the University of Cape Town in South Africa. He co-authored The Large Scale Structure of Space-Time with University of Cambridge physicist Stephen Hawking, published in 1973, and is considered one of the world's leading theorists in cosmology. He is an active Quaker and in 2004 he won the Templeton Prize. From 1989 to 1992 he served as President of the International Society on General Relativity and Gravitation. Currently he is President of the International Society for Science and Religion. Ellis was a vocal opponent of apartheid during the National Party reign in the 1970s and 1980s, and it is during this period that Ellis' research has focused on the more philosophical aspects of cosmology, for which he won the Templeton Prize. He was also awarded the Order of the Star of South Africa by Nelson Mandela, in 1999. On May 18, 2007, he was elected a Fellow of the British Royal Society. In 2005 Ellis appeared as a guest speaker at the Nobel Conference in St. Peter, Minnesota. Born in 1939 to George Rayner Ellis, a newspaper editor, and Gwendoline Hilda MacRobert Ellis in Johannesburg, George Francis Rayner Ellis attended the University of Cape Town, where he graduated with honours in 1960 with a Bachelor of Science degree in physics with distinction. He represented the university in fencing, rowing and flying. While a student at Cambridge University, where he received a PhD. in appli...More: http://booksllc.net/?id=840527 ... Read more

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This digital document is an article from Newsmakers 2004 Cumulation, brought to you by Gale®, a part of Cengage Learning, a world leader in e-research and educational publishing for libraries, schools and businesses.The length of the article is 2091 words.The article is delivered in HTML format and is available in your Amazon.com Digital Locker immediately after purchase.You can view it with any web browser.Newsmakers provides timely and informative profiles of the world's most interesting people. Separate obituaries provide concise profiles of recently deceased newsmakers. ... Read more

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This digital document is a journal article from Tourism Management, published by Elsevier in 2007. The article is delivered in HTML format and is available in your Amazon.com Media Library immediately after purchase. You can view it with any web browser.

Description:
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Chapters: Joan Crawford, Paula Zahn, Jeane Kirkpatrick, William Inge, Chris Cooper, Elizabeth Mitchell, Clarence Cannon, Annie Potts, Gordon Gilkey, Jonathan Holden, Dawn Wells, Martha Beall Mitchell, Shirley Adele Field, Frances Crowe, Ashley Litton, Emily J. Reynolds, Homer Rainey, William Ashbrook, Leslie Adrienne Miller, Karith Foster. Source: Wikipedia. Pages: 107. Not illustrated. Free updates online. Purchase includes a free trial membership in the publisher's book club where you can select from more than a million books without charge. Excerpt: Joan Crawford (March 23, 1905 May 10, 1977) was an American actress in film, television and theatre. Starting as a dancer in traveling theatrical companies before debuting on Broadway, Crawford was signed to a motion picture contract by Metro-Goldwyn-Mayer in 1925. Initially frustrated by the size and quality of her parts, Crawford began a campaign of self-publicity and became nationally known as a flapper by the end of the 1920s. In the 1930s, Crawford's fame rivaled MGM colleagues Norma Shearer and Greta Garbo. Crawford often played hardworking young women who find romance and financial success. These "rags-to-riches" stories were well-received by Depression-era audiences and were popular with women. Crawford became one of Hollywood's most prominent movie stars and one of the highest paid women in the United States, but her films began losing money and by the end of the 1930s she was labeled "box office poison". After an absence of nearly two years from the screen, Crawford staged a comeback by starring in Mildred Pierce (1945), for which she won the Academy Award for Best Actress. In 1955, she became involved with the Pepsi-Cola Company, through her marriage to company president Alfred Steele. After his death in 1959, Crawford was elected to fill his vacancy on the board of directors but was forcibly retired in 1973. She continued acting in film and television regularly thro...More: http://booksllc.net/?id=45969 ... Read more