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Good model in the field
This work is a model for "substantive" study in the sociology of scientific knowledge. As many other works in the field, Kim's terminologies often burst old boundaries of various fields; sociology, history ofscience, philosophy(epistemology, philosophy of science). Well written, butnot easy for general readers to grasp its overall framework. ... Read more

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When rediscovered at the turn of the century, Mendel's laws were found to be applicable to humans, but from the beginning they were fraught with problems. Sex-linked traits and linked genes defied Mendel's rules. Later, other exceptions were found, including sporadic cases, non-penetrance, variable expressivity, and preferential parental transmission.

In this book, Harry Ostrer observes that some of these problems can be explained by incomplete ascertainment, typing errors and modifying genes. He then goes on to systematically explore the evidence for a number of newer genetic processes that were not foreseen by Mendel and his intellectual heirs, examining the molecular basis for these processes and their effects on transmission and phenotype. He shows that these non-Mendelian processes--gonadal and somatic mosaicism, sex-linked inheritance, mitochondrial transmission, genomic imprinting, accelerated rates of mutation, and viral infection--resolve many of the exceptions to Mendelian inheritance. He also provides a complete review of Mendelian genetics, as well as an overview of the structure and functions of genes, chromosomes, and their products. Thus the book presents a holistic view of human genetics.

In the last chapter, Ostrer grapples with the possibilities for identifying new genetic processes, and with genetic determinism--the view that a person's phenotype is fully subject to his or her genetic constitution. He contends that despite the large number of genetic combinations, phenotypes cannot be predicted precisely, even with sufficient computing power. Genetic processes are frequently modified by environmental exposure or they may be random or stochastic in their occurrence. Hence, there are innate limits to genetic determinism. Although prediction of phenotype based on genotype will improve in the future as all of the human genes are identified, such predictions will always remain imprecise. ... Read more

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This innovative book focuses on the development of the gene theory as a case study in scientific creativity. ... Read more

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Boost grades with an illustrated Biology study guide. You will use it from an undergraduate school all the way to medical school. FREE Cell chapter in the trial version.

Customer Reviews (3)

Complicated
We did not use this product in class, so I cannot give it a true rating.In trying to use this on my own was disastrous.I could not understand the concept.

Good quick reference
This is a very good quick biology reference.It is laminated and punched so it can be clipped into a 3-ring binder.

very good indeed
Cell Biology Quick Study Guide. FREE Cell chapter in trial version.

I heartily recommend this ebook to anyone who wants to learn the science of Biology. The ebook is very well produced. There are excellent illustrations and a useful table of contents. ... Read more

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This study guide and workbook is designed for use in conjunction with "Mendelian Inheritance in Man", particularly its on-line version and the new CDROM edition. It will be useful for medical students, fellows in medical genetics and all who wish to enhance their understanding of the field. Topics covered range widely across medical genetics and include: transmission genetics; principles of clinical genetics; biochemical genetics of Mendelian disorders; gene structure and function; mutation, especially molecular nature and biochemical consequences; developmental genetics; chromosomal aberrations in Mendelian disorders; neoplasia; linkage and mapping; population genetics and evolution; and clinical applications of knowledge in medical genetics, including differential diagnosis, genetic counselling and treatment. Working through sets of questions on various topics in biomedical, molecular and clinical genetics, the user is asked to match columns of terms, provide definitions, or give brief explanations or descriptions. The guide also offers useful hints on how to find answers to questions by using "Mendelian Inheritance in Man" and includes other helpful references. ... Read more

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The field of psychology has been greatly influenced by the study of genetics. Decades of research has demonstrated that both genetic and environmental factors play a role in a variety of behaviors in humans and animals e.g. Grigorenko & Sternberg, 2003. The genetic basis of aggression, however, remains poorly understood. Aggression is a multi-dimensional concept, but it can be generally defined as behavior that inflicts pain or harm on another. Genetic-developmental theory states that individual differences in a continuous phenotype result from the action of a large number of genes, each exerting an effect that works with environmental factors to produce the trait Tremblay et al., 2005. Because this type of trait is influenced by multiple factors, it is more complex and difficult to study than a simple Mendelian trait one gene for one phenotype. ... Read more

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Badly Mutated
Genetics of Aggression(WIKIPEDIA ARTICLE) : Psychology(WIKIPEDIA ARTICLE) , Genetics(WIKIPEDIA ARTICLE) , Aggression(WIKIPEDIA ARTICLE) , Phenotype(WIKIPEDIA ARTICLE) , Gene(WIKIPEDIA ARTICLE) , Mendelian Inheritance(WIKIPEDIA ARTICLE) , Dog Aggression(WIKIPEDIA ARTICLE) , Chromosome Abnormality(WIKIPEDIA ARTICLE) , Heritability (WIKIPEDIA ARTICLE) (Paperback)

Mutation in the metaphorical sense - acutally and EXACT copy of W'pedia articles available for FREE.Don't buy, please. ... Read more

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The “Gale Encyclopedia of Science” is written at a level somewhere between the introductory sources and the highly technical texts currently available. This six-volume set covers all major areas of science and engineering, as well as mathematics and the medical and health sciences, while providing a comprehensive overview of current scientific knowledge and technology. Alphabetically arranged entries provide a user-friendly format that makes the broad scope of information easy to access and decipher. Entries typically describe scientific concepts, provide overviews of scientific areas and, in some cases, define terms.

Product Description
This digital document is an article from Human Biology, published by Thomson Gale on October 1, 2005. The length of the article is 8556 words. The page length shown above is based on a typical 300-word page. The article is delivered in HTML format and is available in your Amazon.com Digital Locker immediately after purchase. You can view it with any web browser.

From the author: KEY WORDS: BASQUES, MITOCHONDRIAL DNA HAPLOGROUPS, Y-CHROMOSOME HAPLOTYPES, FACTOR XI DEFICIENCY, BLOOD GROUPS, FACTOR V LEIDEN, INHERITED DISEASES, ABO BLOOD GROUPS, RH, KELL, DUFFY, HLA, DF508 ([DELTA]F508), CYSTIC FIBROSIS, THROMBOSIS, HEREDITARY HEMOCHROMATOSIS.

Citation Details
Title: The Basques: review of population genetics and Mendelian disorders.
Author: Frederic Bauduer
Publication: Human Biology (Magazine/Journal)
Date: October 1, 2005
Publisher: Thomson Gale
Volume: 77Issue: 5Page: 619(19)

Distributed by Thomson Gale ... Read more

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This digital document is an article from Macmillan Reference USA Science Library: Genetics, brought to you by Gale®, a part of Cengage Learning, a world leader in e-research and educational publishing for libraries, schools and businesses.The length of the article is 1916 words.The article is delivered in HTML format and is available in your Amazon.com Digital Locker immediately after purchase.You can view it with any web browser.A comprehensive collection of articles on all aspects of genetics, from Mendel to the decoding of the human genome. Explains the workings of genes and chromosomes, genetic diseases, and biotechnology. Covers the ethical, legal, and social issues connected to genetic science and includes coverage of careers in the field. ... Read more

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Genetic linkage occurs when particular genetic loci or alleles for genes are inherited jointly. Genetic loci on the same chromosome are physically close to one another and tend to stay together during meiosis, and are thus genetically linked. This is called autosomal linkage. Alleles for genes on different chromosomes are usually not linked, due to independent assortment of chromosomes during meiosis. Because there is some crossing over of DNA when the chromosomes segregate, alleles on the same chromosome can be separated and go to different daughter cells. There is a greater probability of this happening if the alleles are far apart on the chromosome, as it is more likely that a cross-over will occur between them. The relative distance between two genes can be calculated using the offspring of an organism showing two linked genetic traits, and finding the percentage of the offspring where the two traits do not run together. The higher the percentage of descendants that does not show both traits, the farther apart on the chromosome the two genes are. ... Read more

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Gene. History of genetics, Mendelian inheritance, Gene expression, Genetic code, Mutation, Gene targeting, The Selfish Gene, Copy number variation, DNA, Epigenetics, Gene- centered view of evolution, Gene therapy, Genetic algorithm, Genetics, Genome, Genomics, List of human genes, Meme, Pseudogene, Predictive medicine ... Read more

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Mendelian inheritance (or Mendelian genetics or Mendelism) is a set of primary tenets relating to the transmission of hereditary characteristics from parent organisms to their children; it underlies much of genetics. They were initially derived from the work of Gregor Mendel published in 1865 and 1866 which was "re-discovered" in 1900, and were initially very controversial. When they were integrated with the chromosome theory of inheritance by Thomas Hunt Morgan in 1915, they became the core of classical genetics. ... Read more

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This manual describes laboratory methodology for diagnosing inborn errors of metabolism. Each chapter is sufficiently detailed so as to be self-contained, thus enabling any individual to adopt the method in their own laboratory and obviating the need for additional methods of references. The book is unique in that it is the first of its kind to be published in the last 15 years, and individual chapters have been developed by experts in the field citing both established and 'cutting-edge' technology.

Thus, it is sufficiently up-to-date to be applicable to the field of inborn errors of metabolism for all readers and those interested in laboratory diagnosis.

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Johns Hopkins Univ., Baltimore, MD. describing genes and/or phenotypes representing individual genes. The entries are assembled into four catalogs according to which group they relate to. Previous edition: c1994. For students, researchers, and clinicians. CD-ROM and study guide were not published simultaneously. DNLM: Genetics, Medical--bibliography. ... Read more

Customer Reviews (1)

Mendelian Inheritance in man
It's a very important book to consult in my work. We can consult by internet pages but it is not the same. Look for information in a book is a very different experience, when I can do it, I prefered. ... Read more

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This digital document is a journal article from Studies in History and Philosophy of Biol & Biomed Sci, published by Elsevier in 2005. The article is delivered in HTML format and is available in your Amazon.com Media Library immediately after purchase. You can view it with any web browser.

Description:
Philosophers have proposed various kinds of relations between Mendelian genetics and molecular biology: reduction, replacement, explanatory extension. This paper argues that the two fields are best characterized as investigating different, serially integrated, hereditary mechanisms. The mechanisms operate at different times and contain different working entities. The working entities of the mechanisms of Mendelian heredity are chromosomes, whose movements serve to segregate alleles and independently assort genes in different linkage groups. The working entities of numerous mechanisms of molecular biology are larger and smaller segments of DNA plus related molecules. Discovery of molecular DNA mechanisms filled black boxes that were noted, but unilluminated, by Mendelian genetics. ... Read more