Product Description
The citric acid cycle?also known as the tricarboxylic acid cycle (TCA cycle), the Krebs cycle, or more rarely, the Szent-Györgyi-Krebs cycle? is a series of enzyme-catalysed chemical reactions, which is of central importance in all living cells that use oxygen as part of cellular respiration. In eukaryotes, the citric acid cycle occurs in the matrix of the mitochondrion. The components and reactions of the citric acid cycle were established by seminal work from Albert Szent-Györgyi and Hans Krebs. In aerobic organisms, the citric acid cycle is part of a metabolic pathway involved in the chemical conversion of carbohydrates, fats and proteins into carbon dioxide and water to generate a form of usable energy. Other relevant reactions in the pathway include those in glycolysis and pyruvate oxidation before the citric acid cycle, and oxidative phosphorylation after it. In addition, it provides precursors for many compounds including some amino acids and is therefore functional even in cells performing fermentation. ... Read more

Product Description
Hydrogen sulfide (or hydrogen sulphide) is the chemical compound with the formula H2S. This colorless, toxic and flammable gas is partially responsible for the foul odor of rotten eggs and flatulence. It often results from the bacterial break down of sulfites in nonorganic matter in the absence of oxygen, such as in swamps and sewers (anaerobic digestion). It also occurs in volcanic gases, natural gas and some well waters. The odor of H2S is commonly misattributed to elemental sulfur, which is in fact odorless. Hydrogen sulfide has numerous names, some of which are archaic (see table). ... Read more

Product Description
Adult stem cells are undifferentiated ? cells, foundthroughout the body after embryonic development, thatmultiply by ? cell division to replenish dying cells andregenerate damaged tissues. Also known as ? somatic stemcells (from Greek ???????ó?, meaning of the body), they canbe found in juvenile as well as adult animals and humans.Scientific interest in adult stem cells has centered ontheir ability to divide or self-renew indefinitely, andgenerate all the ? cell types of the ? organ from whichthey originate, potentially regenerating the entire organfrom a few cells. Unlike embryonic stem cells, the use ofadult stem cells in research and therapy is not consideredto be ? controversial as they are derived from adult tissuesamples rather than destroyed human ? embryos. They havemainly been studied in ? humans and ? model organisms suchas ? mice and ? rats. ... Read more

Product Description
In biology, the term epigenetics refers to changes in phenotype (appearance) or gene expression caused by mechanisms other than changes in the underlying DNA sequence, hence the name epi- (Greek: over; above) -genetics. These changes may remain through cell divisions for the remainder of the cell's life and may also last for multiple generations. However, there is no change in the underlying DNA sequence of the organism;instead, non-genetic factors cause the organism's genes to behave (or "express themselves") differently. The best example of epigenetic changes in eukaryotic biology is the process of cellular differentiation. During morphogenesis, totipotent stem cells become the various pluripotent cell lines of the embryo which in turn become fully differentiated cells. In other words, a single fertilized egg cell - the zygote - changes into the many cell types including neurons, muscle cells, epithelium, blood vessels etc. as it continues to divide. It does so by activating some genes while inhibiting others. ... Read more

Customer Reviews (1)

IF YOU GOOGLE THE 'PRODUCT' DESCRIPTION...
In biology, the term epigenetics refers to changes in phenotype (appearance) or gene expression caused by mechanisms other than changes in the underlying DNA sequence, hence the name epi- (Greek: over; above) -genetics. These changes may remain through cell divisions for the remainder of the cell's life and may also last for multiple generations. However, there is no change in the underlying DNA sequence of the organism;instead, non-genetic factors cause the organism's genes to behave (or "express themselves") differently. The best example of epigenetic changes in eukaryotic biology is the process of cellular differ

... YOU WILL GO STRAIGHT TO THE SOURCE OF THE BOOK: WIKIPEDIA. ... Read more

Product Description
"This volume contains succinct, yet clear, descriptions of each of these topics and is best suited for readers who are delving into these concepts for the first time." -The Quarterly Review of Biology, 2009

This textbook provides an ideal introduction to computational cell biology for students of biology and bioinformatics. In particular the text focuses on a network-based approach to the study of cellular systems. Almost 30 carefully designed study exercises offer excellent support for those preparing for exams in these subjects, and help introduce the more technical aspects of the topic while keeping maths to a minimum. ... Read more

Customer Reviews (1)

Great book!
This book provides a very nice comprehensive overview of computational systems biology. Most of the state of the art computational techniques are covered by the book. It is a must read book for any new student who wants to do research in computational analysis of biological networks. ... Read more

Product Description
This volume is part of the "Cell Biology" series. It represents comprehensive treatment of a special field in extracellular matrix research which has undergone rapid progress in the past 20 years. Major topics discussed include the composition of basement membranes and their organization into extracellular matrices, the structural analysis of the various components of the basement membrane, and the role of basement membranes in cell-matrix interactions, differentiation and pathology. This volume should be of interest to cellular, molecular and developmental biologists, biochemists, biomedical researchers and pathophysiologists. ... Read more

Product Description
Cellular Proteolytic Systems Edited by Aaron J. Ciechanover & Alan L. Schwartz Within cells, regulation of protein degradation, or proteolysis, is critical to dynamic control of protein levels. Cellular Proteolytic Systems is the first book to provide a detailed and comprehensive summary of advances in the biochemistry, cellular biology, molecular genetics, and physiology of the major proteolytic processes. The field of cellular proteolysis is advancing rapidly and has great potential impact in a variety of research and clinical areas, including AIDS and cancer research and treatment. The editors, pioneers in the field of cellular and protein research, describe our current understanding of the three major cellular proteolytic systems: the ubiquitin system, the lysosomal and vacuolar systems, and physiological and pathophysiological cellular proteolysis. Individual chapters cover topics from the molecular genetics of the ubiquitin system to regulation of autophagy to antigen processing and presentation. Cellular Proteolytic Systems will provide an excellent foundation in the biological basis of protein turnover for cellular, developmental, and molecular biologists. ... Read more

Product Description
Research on cell growth, a fundamental biological process whose understanding may ultimately lead to the control of proliferative diseases such as cancer, is a rapidly moving field. The editors of this collection examine recent advances in this field. ... Read more

Product Description
Cardiac cell biology has come of age.
Recognition of activated or modified signaling molecules by specificantibodies, new selective inhibitors, and fluorescent fusion tags arebut a few of the tools used to dissect signaling pathways andcross-talk mechanisms that may eventually allow rational drug design.Understanding the regulation of cardiac hypertrophy in all itscomplexity remains a fundamental goal of cardiac research. Since theadvancement of adenovirally mediated gene transfer, transfectionefficiency is no longer a limiting factor in the study ofcardiomyocytes. A limiting factor in considering cell transplantion asa strategy to repair the damaged heart is cell availability at theright time. Cardiac gap junctions, intercellular communicationchannels that allow electrical and metabolic coupling and play animportant role in arrhythmogenesis are now understood to be exquisitesensors of cardiac change.
The reports in this volume incLude elegant studies that made use ofcutting edge technological advances and many specialized reagents toaddress these issues. ... Read more