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This volume will explore the latest findings in research into the genetics of breast and reproductive cancers, covering the epidemiological aspects of these cancers, their etiology, the effect of environment on genes and cancer etiology, and how research in this area can lead to development of preventative measures and treatments.

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In the coming decades, as more genes are found which convey predisposition to serious diseases, genetics will play an increasingly important role in the lives of patients seeking psychotherapeutic and family therapy services. To help patients with concerns about inherited predisposition to cancer and genetic testing, mental health professionals need to understand the psychological issues patients and families experience when they confront the prospect of learning what fate has dealt them through their genes. Psychological Aspects of Cancer Genetic Testing offers a thorough base of information about genetics, explanations of what is and is not known about cancer genetics, and descriptions of the genetic counseling process. But most importantly, this volume extensively reviews the psychological problems and dilemmas that patients concerned about hereditary cancer experience. The author skillfully and insightfully delves into personal and emotional concerns, the impact of receiving genetic test results, family and child-related matters, the challenge of making momentous decisions about prophylactic surgery, as well as complex social and ethical issues. Because psychologists and other mental health providers are trained in understanding and optimizing complex family interactions, they are in a prime position to help individuals cope with health-related threats and with the reality of inherited illness. They are, thus, poised to improve the quality of life of patients with issues related to the impact of hereditary cancer predisposition. ... Read more

Customer Reviews (1)

Offers a basic grounding in the burgeoning field of genetics
Although Genetic Testing For Cancer: Psychological Approaches For Helping Patients And Families offers a basic grounding in the burgeoning field of genetics and its ability to predict cancer risks, its primary focus is upon the psychological dilemmas that patients concerned about the possibility of hereditary cancer must deal with. Covering the emotional impact of test results, family and child matters, decisions about prophylactic surgery, social and ethical issues, and much more, Genetic Testing For Cancer covers its subject in an evenhanded manner, discussing various difficulties in terms especially intended for psychologists, therapists, and mental health providers. Black-and-white diagrams illustrate this thoroughly researched and highly recommended assembly of professional techniques.
... Read more

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This book by a scientist whose background is in cellular and molecular biology examines the fearsome disease that strikes one in eight women in the United States. Although women are more likely to die of heart disease or of lung cancer, a diagnosis of breast cancer is the medical pronouncement that a woman is most likely to fear. It kills more than 40,000 Americans annually.

Why are some women more vulnerable than others? The interplay between genetics and environment is suspected.

Thus this book for general readers will help them understand the genetic bases of both sporadic and inherited breast cancers. Although only five to ten percent of breast cancer patients have inherited mutations in these genes, all women need to understand the genetic implications of the disease. In clear, concise language Barbara T. Zimmerman guides the reader through the complexities, discussing in detail the genes that are known to increase susceptibility and the ways they are passed on.

Examining the general biology of breast cancer, Zimmerman describes how sporadic and inherited forms of the disease arise and how the location of the tumors can affect the body. She discusses genetic mutations and their roles in the development of tumors and tells how these potentially cancer-inducing genes were discovered.

Covered too are the issues of risk, prevention, screening, diagnosis, therapy, and genetic testing and counseling. Zimmerman concludes with a comprehensive analysis of current research and with an emphasis on how a woman's understanding of inherited breast cancer can help doctors seeking to design better methods for prevention and therapy. A useful list of resources for further information about the genetic causes of breast cancer is included.

Barbara T. Zimmerman did her graduate work in experimental pathology and her post-doctoral research in the cellular and molecular processes of disease. Widely published, she is the manager of the Denver-based firm Biomedical Communication and Consulting. ... Read more

Customer Reviews (1)

Breast cancer genetics made easy
This is a wonderfully well written book in concise form for easy reading.
The content is as up to date, as anyone can wish, containing all the latest information on the genetics of breast cancer not easily found in other publications.
I have already found it extremely useful and have referred to it in lectures to doctors and medical students.

I am happy to pocess this book ... Read more

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Forensic Buff
I have heard so much about cancer and now that my husband has lung cancer, I needed all the information I could read.Thank you so much. ... Read more

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The Biology of Cancer is a textbook for undergraduate and graduate biology students as well as medical students studying the molecular and cellular bases of cancer. The book presents the principles of cancer biology in an organized, cogent, and in-depth manner. The clarity of writing and the lucid full-color art program make the book accessible and engaging. The information unfolds through the presentation of key experiments which give readers a sense of discovery and provides insights into the conceptual foundation underlying modern cancer biology.

The Biology of Cancer synthesizes the findings of three decades of recent cancer research and proposes a conceptual framework from which to teach about these discoveries. It provides the necessary structure, organization, and content for a course on cancer biology for advanced undergraduates and beginning doctoral students. The book is comprehensive and offers many pedagogical features to assist teaching and learning. The book includes many recent and topical references, and is intended to empower the student to move directly into the primary research literature.

The text is up-to-date and provides current information on topics such as tumor stem cells and recently introduced chemotherapeutics. State-of-the-art techniques are discussed throughout. Modern biomedical research is explored, helping readers to hone their analytical abilities and to assimilate and think clearly about complex biological processes. The Biology of Cancer provides insights into many aspects of immunology, developmental biology, and neurobiology.

The exceptional full-color art program contains many images published for the first time. The book is extensively illustrated with schematic drawings, micrographs, computer-generated models and graphs. The pieces were chosen to support and clarify the concepts, as well as to supply additional interest.

Besides its value as a textbook, The Biology of Cancer will be a useful reference for individuals working in biomedical laboratories, and for clinical professionals.

Customer Reviews (37)

... better than described
The book got here in time, and in a condition better than described. The seller was very prompt with replying messages,and what blew me away was the good luck note attached to the book.
Thanks, I really appreciate your services. I will recommend people purchase items from this seller.

Good, not perfect yet
This book was awaited for long. Weinberg's writing style is excellent. The book covers major topic of the molecular biology of cancer. Compared to some other comprehensivebooks on cancer, this book is focused on the molecular events in cancer, and not on particular cancer types, or similar, more clinical topics. Yet (being a cancer researcher myself) I feel that some controversies were left out. One may say that in the textbook one is to present established knowledge, however we are witnessing every day that many dogmas are overthrown. This being a 1st edition, there is still a space for improvements. However, I recommend this book for undergraduates, graduates and professionals.

Great introduction to the cell biology underlying cancer
Highly recommended to me by a physician scientist colleague for an overview of the role of mitochondria in cancer.Those chapters were superb.CD with color figures from the book is great.Wish all first/second year medical students had to read this book.

Very readable serious scientific introduction for the college student/first-second year medical student/graduate student.

A good book for undergraduates, PhD students, physician scientists
This book contains tremendous amount of information, covering history, bench works, and medicine (cancer). i believe the author spent tremendous time and effort to finish this book. it is well-organized and well-written. i strongly recommend this book to undergraduates, PhD students, and physician scientists.

Excellent! Great Book.
I bought this book as a resource for my research. Is really easy to keep track of every single thing you are reading about. I really recommend it! Also about the cd is very useful if you need some particular graphic, diagram or even a picture. ... Read more

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Reveals what leading experts have recently discovered about cancers caused by DNA alterations!

The second edition of THE GENETICS OF CANCER, newly titled THE GENETIC BASIS OF HUMAN CANCERS, updates and informs on the most recent progress in genetic cancer research and its impact on patient care.With contributions by the foremost authorities in the field, this fascinating new edition reports on how to understand and predict tumor development - information that can enhance decision-making and advance genetic research.

2ND Edition Highlights

NEW CHAPTERS:
* Peutz-Jeghers syndrome
* Juvenile polyposis syndrome
* Tumor genome instability
* Gene expression profiling in cancer
* Pilomatricoma and pilomatrix carcinoma
* Hereditary paragangliomas of the head and neck
* Cylindromatosis
* Familial cardiac myxomas and carney complex
* Cancers of the oral cavity and pharynx
* Genetic abnormalities in lymphoid malignancies

THOROUGHLY REVISED:
* Every chapter has been meticulously reviewed and revised to incorporate the most recent research and clinical findings
* Includes a valuable introduction by renowned editors Vogelstein & Kinser
* Features 150 MORE illustrations than the previous edition ... Read more

Customer Reviews (2)

Thumbs up.
Great text for any graduate student to get an understanding of the genetics of cancer. This book has something in it for everybody and is divided into the following areas: Basic concepts, cell cycle control, familial cancer syndromes and cancers by site.

It is a great text for a graduate student interested in cancer and does proved a very extensive introduction for an advanced student. It is an excellent source of reviews for a graduate student. It's of course not recommended for any lay audience. I use it often as great reference. The drawback is that it is not a good introductory text but one that would help you build upon your previous understanding and looks at the subject area quite in-depth.

Decent job trying to review all of cancer
First of all I was dissapointed there were no color illustrations.The book is broken up into first, a few chapters on basic concepts in cancer.Next, chapters which deal with Familial cancers (like bloom's syndrome orAtaxia-telaniectasia, or breast cnacer) and then chapters on cancers bygeneral location(stomach, lung).It is definitely a book for a moreprofessional audience.The chapter's do a decent job reviewing theclinical aspects each cancer type. The molecular biology is at times too indepth and at other times already showing its age.We used some chaptersfrom this book as reviews for a course I was taking in grad. school. Overall I thought it was pretty interesting. ... Read more

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This concise guidebook consolidates the main concepts of the cancer gene theory, and provides a framework for understanding the genetic basis of cancer. Focused on the most highly representative genes that underlie the most common cancers, the book is aimed at advanced undergraduates who have completed introductory courses in genetics, biology and biochemistry, medical students, and house medical house staff preparing for board examinations. Primary attention is devoted to the origins of cancer genes and the application of evolutionary theory to explain why the cell clones that harbor cancer genes tend to expand.

Customer Reviews (2)

A Wonderful Short Overview of Cancer Genetics
I had this sitting on my shelf as a backup reference for a few months and finally opened the book. At first I was not impressed but when I began reading it the book is exceptional in its clarity and scope of presentation. If one has read Weinberg, the bible if cancer genetics introduction, then this appears to be quite a step down, but in reality it distills and focuses the topics exceptionally well. Whereas Weinberg goes into massive detail, and rightly so, Bunz focuses on a laser with short clear descriptions and presentations.

Chapter 1 details the now well understood ways in which cell DNA destruction happens. There is a good short presentation of the Vogelstein model and a setting up of the genetic flows which control the steps in the conversion of cells to the metastatic state. The graphics are crisp and well done and satisfy the point to be made.

Chapter 2 is on oncogenes and the chapter provides a good historical perspective and also establishes the lead in for the following chapters. The viral oncogene discussion is typical for its clarity and briefness. It reads very well to the experienced eye and I suspect it will do as well for the uninitiated. I also found the PIK3CA discussion on kinases exceptionally well done and useful for staging the follow on topics.

Chapter 3 on tumor supressor genes is also well done. The discussion on APC and p53 is a good overview and provides adequate basis for building on the topic.The PTEN discussion also establishes the now well understood need to focus on PTEN since it plays such a critical role in many cancers such as that of the prostate.

Chapter 4 is on gene instability and puts all of the elements together.

Chapter 5 is in my opinion the best and it is on the pathways. This is a significant area because by understanding what they are and how to control them perhaps a wealth of treatment options may become available.The author starts with the full pathway map and then goes pathway by pathway. I found the discussion here more focused and clearer than Weinberg. Clearly Weinberg is the gold standard but by reading through Bunz Chapter 5 one can get a short focused and integrated discussion.

Chapter 6 then takes these principles and looks at them from a cancer by cancer set of lenses. This is useful and it allows the reader to focus in on specifics and what is known and not known.

Chapter 7 provides a brief clinical overview.

All in all a superb little gem worth being on many a desk. I find it is worth going back to from time to time.

Yet there is a gap in the literature that this could have addressed, that is the development of true pathway modeling. The ability to link proteins and enzymes to genes, the detailed epigenetic controls, and the catalyst of secondary pathways and inter-cellular communications. Perhaps it is still too early since much of this is yet to be developed in a fully systematic fashion in the literature.

Very nice new book on cancer genetics
This new book on Cancer Genetics, written in its entirety by Dr. Fred Bunz of Johns Hopkins School of Medicine, provides a a very nice introduction to modern Cancer Genetics. It is appropriate for advanced undergraduates and graduate students, as well as medical students. The writing is lucid and concise, and the many figures and diagrams provide useful visual emphasis for particularly important points. Overall, this is an outstanding new volume that would provide a useful backdrop for courses in Cancer Genetics and Biology, as well as being a useful laboratory reference. ... Read more

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Cancer Genetics is a collection of chapters covering the key recent developments in cancer genetics which have an impact on clinical care.  The target audience will be physicians and scientists who need to be apprised on the most recent developments in the field. ... Read more

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This is a comprehensive and up-to-date guide to the diagnosis, clinical features and management of inherited disorders conferring cancer susceptibility. This new edition is fully updated with much more molecular, screening and management information. It covers risk analysis and genetic counseling for individuals with a family history of cancer, and also discusses predictive testing and the organization of the cancer genetics service. It aims to provide such details in a practical format for geneticists and clinicians in all disciplines. This book differs from others in the field in that it is a practical handbook for easy reference for a wide clinical audience. There is a large reference list for further details, as well as information about the genes causing mendelian cancer predisposing condition and their mechanism of action. ... Read more

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Advances in genetics are transforming estimates of an individual’s risk of developing cancer and approaches to prevention and management of cancer in those who may have increased susceptibility. Identifying and caring for patients with hereditary cancer syndromes and their family members present a complex clinical, scientific and social challenge. This textbook, by leading experts at Massachusetts General Hospital Cancer Center, highlights the current understanding of the genetics of hereditary cancers of the breast, ovary, colorectum, stomach, pancreas, kidney, skin, and endocrine organs. Practical guidelines for the use of genetic testing, cancer screening and surveillance, prophylactic surgery, and promising targeted therapeutic agents are discussed.

In addition, ongoing research involving genome-wide screens to identify novel modest risk-associated genetic loci are explored, along with new approaches to the application of genetic markers in guiding therapeutic options.

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This publication surveys the profound and far-reaching ramifications that have arisen from the very significant advances in understanding the genetic basis of familial breast and ovarian cancer. Written by international experts from Europe and North America, this book provides the busy clinician with a contemporary and wide-ranging guide to the latest developments in diagnosis, genetics, screening, prevention, and management. In addition, the volume discusses ethical and insurance issues, distinct cultural differences in breast cancer and use of recently devised cancer genetics clinics. The different referral criteria and patterns to these clinics are detailed. ... Read more

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This issue serves as a timely review of both the genetic and genomic factors resulting in a predisposition to human cancer.  There is now strong evidence to support the use of genetic testing for cancer predisposition in the practice of preventive medicine, and at the same time, there is emerging new literature defining the role of genomic approaches to assessment of cancer predisposition.  Articles address predisposition syndromes in the areas of breast cancer, lower GI cancer, genitourinary cancer, pediatric cancer, endocrine cancer, and hematologic malignancy. ... Read more

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The preeminent book on cancer cytogenetics—now in a valuable new edition

Like its successful predecessors, Cancer Cytogenetics, Third Edition continues to offer authoritative coverage of neoplastic processes at the chromosomal level of genomic organization. Now updated and expanded, this new edition includes detailed information on the most recent advances in the field, incorporating a vast amount of new cytogenetic as well as molecular genetic data from the latest basic and clinical investigations.

Edited by two leading authorities, who are now aided by a panel of internationalexperts, this new edition has been updated to include:

• Greatly expanded coverage of solid tumors

• Enhanced coverage of acute and chronic myeloproliferative disorders

• The latest findings on acute and chronic lymphoproliferative disorders

Cancer Cytogenetics, Third Edition is a valuable resource for researchers in a wide range of fields, including cytogenetics, medical and molecular genetics, cellular and molecular biology, oncology, and hematology. With its complete coverage of thecytogenetic mechanisms underlying neoplasia, and always with a keen eye on the clinical consequences of the various acquired genetic aberrations, this text will alsobe an indispensable reference for all clinicians involved in the diagnosis and treatment of cancer patients. ... Read more

Customer Reviews (2)

Still the best reference
My thesis advisor insisted that I had to read this book. It's been almost 10 years and I keep going back to it. It's a gem!

A staple in our lab
As of early 2003, it is still the most-used reference in our cytogenetics lab when we analyze bone marrow or tumor samples. We can use it for guidance as we begin analyzing a sample and once we find abnormalities, we can learn what genes are likely at work. I truly hope there is a revised edition in the works! ... Read more

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Plant protease inhibitors are diverse in number and in specificity towards various proteolytic enzymes. This book focuses on the isolation, structure, characterization, physiochemical and physiological properties, synthesis, functions and mechanisms of action of plant protease inhibitors. It deals with their inhibitory effects on insects and pathogens and with their induction and introduction into plants by genetic engineering for plant protection. The induced resistance of insects to the inhibitors and the hazards to friendly insects are also discussed. Further, findings are presented on the cancer chemopreventive properties of the inhibitors at the cellular, tissue and organ levels and in the organism.

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With a Foreword by Richard D. Klausner, M.D., Director, National Cancer Institute and an Introduction by Henry T. Lynch, M.D., President, Hereditary Cancer Institute and Director, Creighton Cancer Center, Creighton University.

When ordering a genetic test to determine whether a patient is susceptible to genetically transmitted cancers, physicians must be prepared to cope with profound medical, psychological, and ethical consequences. They, along with genetic counselors, nurses, psychologists, and other health professionals, must ensure that interpretations of test results are accurate, risk assessments are appropriate, and the communication of risk information is clear, helpful, and productive.

Clinical Cancer Genetics: Risk Counseling and Management is a comprehensive practical guide for health professionals responding to the growing demand for clinical cancer genetic services. Using examples drawn from actual cases and emphasizing fundamental principles throughout, this book outlines the scope of clinical cancer genetics and its underlying scientific concepts, reviews the most prevalent syndromes of cancer predisposition, and addresses major issues associated with genetic testing, including:
* Use of quantitative methods in risk counseling
* Methodologies of genetic testing
* Genetic testing of patients with cancer
* Reproductive risk counseling of cancer patients
* Special psychological, ethical, and legal challenges in clinical cancer genetics

Supplemented with practical materials used in cancer genetic counseling programs and an annotated table of selected human cancer predisposition syndromes, Clinical Cancer Genetics: Risk Counseling and Management equips health care professionals with a complete understanding of the benefits and limitations of genetic testing technologies and the ability to integrate genetic information into the management of patients who are at risk or already affected by cancer. ... Read more

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From prevention and screening to treatment and palliation, advances in genetics research are influencing every aspect of the cancer continuum. In the next decade, nurses practicing in an oncology setting will have a unique opportunity to introduce new genetic concepts into counseling, education, and direct care giving.

Genetics in Oncology Practice: Cancer Risk Assessment provides your students with ways to meet the challenge and opportunity of this emerging field. Applicable across a wide range of clinical settings and practice specialties, this new text details how nurses can utilize genetics in their everyday practice. ... Read more

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In Building Genetic Medicine, Shobita Parthasarathy shows how, even in an era of globalization, national context is playing an important role in the development and use of genetic technologies. Focusing on the development and deployment of genetic testing for breast and ovarian cancer (known as BRCA testing) in the United States and Britain, Parthasarathy develops a comparative analysis framework in order to investigate how national "toolkits" shape both regulations and the architectures of technologies and uses this framework to assess the implications of new genetic technologies.

BRCA testing was one of the most highly anticipated and publicized technologies of contemporary medicine. Parthasarathy argues that differences in the American and British approaches to health care and commercialization of research led to the establishment of different BRCA services in the two countries. In Britain, the technology was available through the National Health Service as an integrated program of counseling and laboratory analysis, and was viewed as a potentially cost-effective form of preventive care. In the United States, although BRCA testing was initially offered by a number of providers, one company eventually became the sole provider of a test available to consumers on demand.

Parthasarathy also reports on an unsuccessful attempt by the American provider of BRCA testing to market its services in Britain. British scientists, health-care providers, and patients rejected the American technology, she argues, because it was part of a social, economic, and political system to which they were not accustomed. Parthasarathy draws lessons for the future of genetic medicine from these cross-national differences, and discusses the ways in which comparative case studies can inform policy-making efforts in science and technology. ... Read more

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This book examines the principles underlying genetic predisposition to cancer in order to familiarise practising oncologists, geneticists and other professionals interested in cancer with this new and expanded field. The coverage is comprehensive, taking the reader from an introduction to genetic predisposition, through a discussion of the molecular biology and statistical techniques involved in the detection and cloning of predisposition genes to a consideration of familial cancer syndromes, encompassing rare and common cancers. The text also includes a discussion of genetic screening and cancer management options, and a consideration of the associated ethical and psychological issues. To reflect the rapid advances in the field since the first edition, the contents have been thoroughly updated with new chapters on the biological basis of cancer predisposition, population-based studies of susceptibility, Von-Hippel-Lindau syndrome and evaluation of management strategies for individuals at increased cancer risk. ... Read more